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company name :
StressMarq Biosciences
product type :
antibody
product name :
Brevican Antibody
catalog :
SMC-428D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S294A-6
reactivity :
mouse, rat
application :
western blot, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-428D
Product Name :
Brevican Antibody
Description :
Mouse Anti-Rat Brevican Monoclonal IgG2B
Target :
Brevican
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Neurodegeneration Alzheimer's Disease Cell Signaling Scaffold Proteins
Alternative Name(s) :
BCAN Antibody, BEHAB Antibody, CSPG7 Antibody, Brain enriched hyaluronan binding protein Antibody, Brevican core protein Antibody, Brevican core protein isoform 1 Antibody, Brevican core protein isoform 2 Antibody, Brevican proteoglycan Antibody, Chondroitin sulfate proteoglycan 7 Antibody, Chondroitin sulfate proteoglycan BEHAB Antibody, MGC13038 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S294A-6
Immunogen :
Fusion protein amino acids 219-655 of rat Brevican
Immunogen Species :
Rat
Accession Number :
NP_001028837.1
Swiss-Prot :
P55068
Applications :
WB ICC/IF
Host Species :
Mouse
Isotype :
IgG2B
Species Reactivity Abbreviation :
Ms Rt
Species Reactivity Full Name :
Mouse Rat
Antibody Dilution :
WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~140kDa (and smaller due to proteolytic cleavage).
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-428D, RRID: AB_2701451
Certificate of Analysis :
1 µg/ml of SMC-428 was sufficient for detection of Brevican in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Extracellular Space Extracellular Matrix Membrane Lipid-Anchor GPI-Anchor
Scientific Background :
Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.
References :
1. Yamada H., Watanabe K., Shimonaka M. and Yamaguchi Y. (1994) J. Biol. Chem. 269: 10119-10126. 2. Yamada H., Watanabe K., Shimonaka M., Yamasaki M. and Yamaguchi Y. (1995) Biochem. Biophys. Res. Commun. 216: 957-963. 3. Rauch U., et al. (1997) Genomics 44: 15-21. 4. Zhang H., Kelly G., Zerillo C., Jaworski D.M. and Hockfield S. (1998) J. Neurosci. 7: 2370-2376. 5. Aspberg A., Adam S., Kostka G., Timpl R. and Heinegard D. (1999) J. Biol. Chem. 274: 20444-20449.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-428-Brevican-Antibody-S294A-6-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-428_Brevican_Antibody_S294A-6_WB_Rat_Brain-Membrane_1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.