product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
GluN1/NR1 Antibody
catalog :
SMC-410D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S308-48
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-410D
Product Name :
GluN1/NR1 Antibody
Description :
Mouse Anti-Rat GluN1/NR1 Monoclonal IgG1
Target :
GluN1
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Cell Signaling Neuroscience Neurotransmitter Receptors Glutamate Receptors NMDA Receptors
Alternative Name(s) :
NMDAR1 Antibody, NMDA Receptor 1 Antibody, NMDAR Antibody, NMDA1 Antibody, GRIN1 Antibody, Glutamate [NMDA] receptor subunit zeta-1 Antibody, Glutamate receptor ionotropic N methyl D aspartate 1 Antibody, MRD8 Antibody, N methyl D aspartate receptor Antibody, N methyl D aspartate receptor channel subunit zeta 1 Antibody, N methyl D aspartate receptor subunit NR1 Antibody, NMD-R1 Antibody, NMDA 1 Antibody, NMDA R1 Antibody, NMDZ1_HUMAN Antibody, NR1 Antibody, GluN1 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S308-48
Immunogen :
Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
Immunogen Species :
Rat
Accession Number :
NP_058706.1
Swiss-Prot :
P35439
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~105kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-410D, RRID: AB_11229703
Certificate of Analysis :
1 µg/ml of SMC-410 was sufficient for detection of NR1 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Cell Membrane Cell Junction Synapse Postsynaptic Cell Membrane
Scientific Background :
The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function (1). The NMDA receptor forms a heterotetramer between two NR1 and two NR2 subunits (the subunits are also called glutamate-binding NMDA receptor subunits or GluN for short); two obligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits.
References :
1. Li F., and Tsien J.Z. (2009) New England J. Medicine. 361: 302-303. 2. Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547. 3. Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282(35): 25299-25307.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-410-GluN1-NR1-Antibody-S308-48-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-410_NMDAR1-NMDA-receptor_Antibody_S308-48_WB_Rat_brain-membrane-lysate_1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.