product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
Clcn3 Antibody
catalog :
SMC-408D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S258-5
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-408D
Product Name :
Clcn3 Antibody
Description :
Mouse Anti-Rat Clcn3 Monoclonal IgG1
Target :
ClCN3
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Pumps/Transporters Ion Pumps/Transporters Cell Signaling
Alternative Name(s) :
CIC3 Antibody, CLC3 Antibody, CLCN 3 Antibody, Chloride channel 3 Antibody, Chloride channel protein 3 Antibody, Chloride channel Antibody, voltage-sensitive 3 Antibody, Chloride transporter ClC 3 Antibody, DKFZp564I0463 Antibody, H(+)/Cl(-) exchange transporter 3 Antibody, Chloride transporter ClC-3 Antibody, ClC-3 Antibody, H(+)/Cl(-) exchange transporter 3 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S258-5
Immunogen :
Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
Immunogen Species :
Rat
Accession Number :
NP_445815.2
Swiss-Prot :
P51792
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results).
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-408D, RRID: AB_11229709
Certificate of Analysis :
1 µg/ml of SMC-408 was sufficient for detection of Clcn3 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Membrane Endosome Endosome membrane Cytoplasmic Vesicle Secretory Vesicle Membrane
Scientific Background :
Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.
References :
1.  www.phosphosite.org/proteinAction.do?id=5088&showAllSites=true
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-408-Clcn3-Antibody-S258-5-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-408-CIcn3-Antibody-S258-5-WB-Rat-Brain-Membrane-1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.