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company name :
StressMarq Biosciences
product type :
antibody
product name :
Cav3.1 Antibody
catalog :
SMC-405D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S178A-9
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-405D
Product Name :
Cav3.1 Antibody
Description :
Mouse Anti-Mouse Cav3.1 Monoclonal IgG1
Target :
Cav3.1
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Ion Channels Calcium Channels Voltage-Gated Calcium Channels
Alternative Name(s) :
CACNA1G Antibody, CaV T1 Antibody, Cav3 1 Antibody, cav3 1c Antibody, KIAA1123 Antibody, MGC117234 Antibody, NBR13 Antibody, voltage gated calcium channel cav3.1 Antibody, calcium channel voltage dependent alpha 1G subunit Antibody, calcium channel voltage dependent T type alpha 1G subunit Antibody, calcium channel voltage dependent T type alpha1G subunit Antibody, voltage dependent calcium channel alpha 1G subunit isoform 11 Antibody, voltage dependent T type calcium channel subunit alpha 1G Antibody, Voltage gated calcium channel subunit alpha Cav3 1 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S178A-9
Immunogen :
Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1
Immunogen Species :
Mouse
Accession Number :
NP_001106284.1
Swiss-Prot :
Q9WUT2
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), ICC/IF (1:100);optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~<200kDa. Does not cross-react with Cav3.2.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-405D, RRID: AB_11232605
Certificate of Analysis :
1 µg/ml of SMC-405 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Membrane
Scientific Background :
Calcium channel CaV3.1 (a1G) is a low-voltage-activated T-type calcium channel. Such T-type channels are expressed throughout the body. In the heart, they may be involved in pacemaker current. In neurons, these channels may play a secondary pacemaker role (1). With the ubiquitous expression, it is not surprising that alterations in channel function have been implicated in disease. Drugs that act to block T-type calcium channels are used as anti-hypertensives, antiepileptic's, and blocking of T-type calcium channels may be involved in the action of some anesthetics and antipsychotics as well (1). Much remains to be determined about the precise cellular localization, in vivo physiological roles, roles in disease states and possible routes to modulate their structure/function to ameliorate effects of disease.
References :
1. Perez-Reyes E. (2003). Physiol. Rev., 83: 117-161.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-405_Cav31_Antibody_S178A-9_ICC-IF_Human_SK-N-BE-Cells-Human-Neuroblastoma-cells_60X_Composite_1.png SMC-405_Cav3.1-Calcium-Channel_Antibody_S178A-9_WB_Rat_brain-membrane-lysate_1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.