GABA-B Receptor 2 Antibody | StressMarq Biosciences SMC-402D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

GABA-B Receptor 2 Antibody

catalog :

SMC-402D

quantity :

100 µg

price :

300.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S81-2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

StressMarq Biosciences product webpage

product information

Catalog No :

SMC-402D

Product Name :

GABA-B Receptor 2 Antibody

Description :

Mouse Anti-Rat GABA-B Receptor 2 Monoclonal IgG1

Target :

GABA B Receptor 2

Conjugate :

Unconjugated

2021 List Price :

300.00 USD

Currency :

USD

Research Area(s) :

Neuroscience Neurotransmitter Receptors GABA Receptors GABAB Receptors

Alternative Name(s) :

BcDNA:GH07312 Antibody, CG6706 Antibody, CT20836 Antibody, D GABA[[B]]R2 Antibody, D Gaba2 Antibody, FLJ36928 Antibody, G protein coupled receptor 51 Antibody, G-protein coupled receptor 51 Antibody, GAB B R2 Antibody, GABA B R2 Antibody, GABA B receptor 2 Antibody, GABA B RECEPTOR Antibody, GABA-B receptor 2 Antibody, GABA-B-R2 Antibody, GABA-BR2 Antibody, GABA[[B]]R2 Antibody, GABAB R2 Antibody, GABABR 2 Antibody, GABABR2 Antibody, GABB R2 Antibody, GABBR 2 Antibody, GABBR2 Antibody, GABR2_HUMAN Antibody, Gamma aminobutyric acid (GABA) B receptor 2 Antibody, Gamma aminobutyric acid B receptor 2 Antibody, Gamma aminobutyric acid GABA B receptor 2 Antibody, Gamma aminobutyric acid type B receptor subunit 2 Antibody, Gamma-aminobutyric acid type B receptor subunit 2 Antibody, Gb 2 Antibody, Gb2 Antibody, GH07312 Antibody, GPR 51 Antibody, GPR51 Antibody, GPRC 3B Antibody, GPRC3B Antibody, HG 20 Antibody, HG20 Antibody, HRIHFB2099 Antibody, Metabotropic GABA B receptor subtype 2 Antibody, OTTHUMP00000021776 Antibody, OTTHUMP00000063797 Antibody, R2 SUBUNIT Antibody

Size :

100 µg

Category :

Antibodies

Product Type :

Monoclonal

Clone Number :

S81-2

Immunogen :

Fusion protein amino acids 861-912 of rat GABA(B)R2

Immunogen Species :

Rat

Accession Number :

NP_113990.1

Swiss-Prot :

O88871

Applications :

WB IHC ICC/IF

Host Species :

Mouse

Isotype :

IgG1

Species Reactivity Abbreviation :

Hu Ms Rt

Species Reactivity Full Name :

Human Mouse Rat

Antibody Dilution :

WB (1:1000); optimal dilutions for assays should be determined by the user.

Purification :

Protein G Purified

Storage Buffer :

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Concentration :

1 mg/ml

Specificity :

Detects ~105kDa. No cross-reactivity against GABA(B)R1.

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SMC-402D, RRID: AB_11232611

Certificate of Analysis :

1 µg/ml of SMC-402 was sufficient for detection of GABA(B)R2 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Cellular Localization :

Cell Membrane Cell Junction Synapse Postsynaptic Cell Membrane

Scientific Background :

GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).

References :

1. Jones K.A,. et al. (2000) Neuropsychopharmacology 23: S41-9. 2. Duthey B., et al. (2002) J Biol Chem. 277: 3236-41. 3. Kaupmann K., et al. (1997) Nature 386: 239-46.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SMC-402-GABA-B-Receptor-2-Antibody-S81-2-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-402_GABA-B-Receptor-2_Antibody_S81-2_WB_Rat_Brain-Membrane_1.png

more info or order :

StressMarq Biosciences product webpage