MMP9 Antibody | StressMarq Biosciences SMC-396D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

MMP9 Antibody

catalog :

SMC-396D

quantity :

100 µg

price :

300.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S51-82

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

StressMarq Biosciences product webpage

citations: 3

Reference
Patrizz A, Doran S, Chauhan A, Ahnstedt H, Roy O Reilly M, Lai Y, et al. EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke. Aging (Albany NY). 2020;12:5121-5139 pubmed publisher
Ritzel R, Lai Y, Crapser J, Patel A, Schrecengost A, Grenier J, et al. Aging alters the immunological response to ischemic stroke. Acta Neuropathol. 2018;136:89-110 pubmed publisher
Ritzel R, Patel A, Pan S, Crapser J, Hammond M, JELLISON E, et al. Age- and location-related changes in microglial function. Neurobiol Aging. 2015;36:2153-63 pubmed publisher

product information

Catalog No :

SMC-396D

Product Name :

MMP9 Antibody

Description :

Mouse Anti-Rat MMP9 Monoclonal IgG2a

Target :

MMP9

Conjugate :

Unconjugated

2021 List Price :

300.00 USD

Currency :

USD

Research Area(s) :

Cardiovascular System Angiogenesis Cardiovascular Growth Factors Adhesion / Extracellular Matrix Matrix Metalloproteinases Cell Signaling Extracellular Matrix (ECM) Enzymes Cell Signaling Extracellular Matrix (ECM) Enzymes Cancer Tumor Biomarkers Tumor Biomarker Enzymes Cancer Invasion/microenvironment

Alternative Name(s) :

MMP-9 Antibody, CLG4B Antibody, 82kDa matrix metalloproteinase-9 Antibody, collagenease type 4 beta Antibody, GELB Antibody, Macrophage gelatinase Antibody, MANDP2 Antibody, Type V collagenase Antibody, 92 kDa gelatinase Antibody, 92 kDa type IV collagenase Antibody, Gelatinase B Antibody, MMP9 Antibody, Matrix metalloproteinase 9 Antibody

Size :

100 µg

Category :

Antibodies

Product Type :

Monoclonal

Clone Number :

S51-82

Immunogen :

Fusion protein amino acids 1-708 (full length) of rat MMP9

Immunogen Species :

Rat

Accession Number :

NP_112317.1

Swiss-Prot :

P50282

Applications :

WB IHC ICC/IF IP FCM

Host Species :

Mouse

Isotype :

IgG2a

Species Reactivity Abbreviation :

Hu Ms Rt

Species Reactivity Full Name :

Human Mouse Rat

Antibody Dilution :

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Purification :

Protein G Purified

Storage Buffer :

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Concentration :

1 mg/ml

Specificity :

Detecs ~92kDa and ~82kDa (pro and active forms).

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SMC-396D, RRID: AB_11232604

Certificate of Analysis :

1 µg/ml of SMC-396 was sufficient for detection of MMP9 in 20 µg of COS-1 cells (lysate) transfected with human MMP9 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Cellular Localization :

Extracellular Matrix

Scientific Background :

MMP9, otherwise known as matrix metalloproteinase 9, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes like arthritis and metastasis (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).

References :

1. Hirose Y., et al. (2008) Am J Hum Genet. 82(5): 1122-1129. 2. Coussens L.M., et al. (2002) Science 295: 2387-2391. 3. Sternlicht M.D., et al. (1999) Cell 98: 137-146. 4. Vu T.H., et al. (1998) Cell 93: 411-422. 5. Nagase H., et al. (1990) Biochemistry 29: 5783-5789.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SMC-396_MMP9_Antibody_S51-82_ICC-IF_Mouse_NIH-3T3-Mouse-Fibroblast-cell-line_60X_Composite_1.png SMC-396_MMP9_Antibody_S51-82_WB_Rat_Brain_1.png

more info or order :

StressMarq Biosciences product webpage