product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
Sodium-Iodide Symporter Antibody
catalog :
SMC-390D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
14F
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-390D
Product Name :
Sodium-Iodide Symporter Antibody
Description :
Mouse Anti-Human Sodium-Iodide Symporter Monoclonal IgG1
Target :
Sodium Iodide Symporter
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Pumps/Transporters Ion Pumps/Transporters Cell Signaling Cancer
Alternative Name(s) :
NIS Antibody, SLC5A5 Antibody, solute carrier family 5 Antibody, Na (+)I(-) cotransporter Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
14F
Immunogen :
Mannose binding protein hNIS fusion (AA468-643)
Immunogen Species :
Human
Accession Number :
NP_000444.1
Swiss-Prot :
Q92911
Applications :
WB IHC AM
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~97kDa, non-glycosylated version at 68kDa. Other minor bands associated with hNIS at 160kDa, and degradation products at ~30 kDa, and ~15kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-390D, RRID: AB_10804544
Certificate of Analysis :
1 µg/ml of SMC-390 was sufficient for detection of hNIS in 20 µg of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Membrane
Scientific Background :
The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3).
References :
1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460. 2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558. 3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-390_Sodium-Iodide-Symporter_Antibody_14F_WB_Human_thyroid-lysate_1.png SMC-390_Sodium-Iodide-Symporter_Antibody_14F_IHC_Mouse_Trachea_1.png SMC-390_Sodium-Iodide-Symporter_Antibody_14F_IHC_Mouse_Thyroid_2.png SMC-390_Sodium-Iodide-Symporter_Antibody_14F_IHC_Mouse_Thyroid_3.png
SMC-390_Sodium-Iodide-Symporter_Antibod
y_14F_IHC_Mouse_Thyroid_1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.