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company name :
StressMarq Biosciences
product type :
antibody
product name :
BK Beta 3a Antibody
catalog :
SMC-330D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S40B-18
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-330D
Product Name :
BK Beta 3a Antibody
Description :
Mouse Anti-Mouse BK Beta3a Monoclonal IgG1
Target :
KCNMB3
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Ion Channels Potassium Channels Calcium-Activated Potassium Channels Cancer Cell Signaling
Alternative Name(s) :
HBETA3 Antibody, KCNMB2 Antibody, KCNMBL Antibody, BKBeta3 Antibody, KCNMB3 Antibody, Calcium-activated potassium channel subunit beta-3 Antibody, BK channel subunit beta-3 Antibody, BKbeta3 Antibody, Hbeta3 Antibody, Calcium-activated potassium channel Antibody, subfamily M subunit beta-3 Charybdotoxin receptor subunit beta-3 Antibody, K(VCA)beta-3 Antibody, Maxi K channel subunit beta-3 Antibody, Slo-beta-3 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S40B-18
Immunogen :
Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a
Immunogen Species :
Mouse
Accession Number :
NP_055222.3
Swiss-Prot :
Q9NPA1
Applications :
WB IHC ICC/IF IP AM
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~32 kDa. No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-330D, RRID: AB_2131378
Certificate of Analysis :
1 µg/ml of SMC-330 was sufficient for detection of BK Beta3a in 10 µg of COS cell (lysate) transiently transfected with BKbeta3a by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Membrane
Scientific Background :
BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (1). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (2). This has major implications on other physiological processes in tissues other than the brain.
References :
1. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1-13. 2. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481-1489.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-330_KCNMB3-Potassium-Channel_Antibody_S40B-18_ICC-IF_Human_HaCaT-cells_1.png SMC-330_KCNMB3-Potassium-Channel_Antibody_S40B-18_WB_Rat_brain-membrane-lysate_1.png SMC-330_KCNMB3-Potassium-Channel_Antibody_S40B-18_IHC_Mouse_backskin_1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.