SHANK (pan) Antibody | StressMarq Biosciences SMC-327D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

SHANK (pan) Antibody

catalog :

SMC-327D

quantity :

100 µg

price :

300.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S23b-49

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

StressMarq Biosciences product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, et al. Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Mol Brain. 2012;5:43 pubmed publisher
	Ferrara N, Cullen P, Pullins S, Rotondo E, Helmstetter F. Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination. Learn Mem. 2017;24:414-421 pubmed publisher

product information

Catalog No :

SMC-327D

Product Name :

SHANK (pan) Antibody

Description :

Mouse Anti-Rat SHANK (pan) Monoclonal IgG1

Target :

SHANK

Conjugate :

Unconjugated

2021 List Price :

300.00 USD

Currency :

USD

Research Area(s) :

Neuroscience Cell Markers Neuron Markers Postsynaptic Markers Cell Signaling Scaffold Proteins

Alternative Name(s) :

Cortactin binding protein 1 Antibody, Cortactin SH3 domain-binding protein Antibody, Cortactin-binding protein 1 Antibody, CortBP1 Antibody, CTTNBP1 Antibody, GKAP/SAPAP interacting protein Antibody, GKAP/SAPAP-interacting protein Antibody, KIAA1022 Antibody, Proline rich synapse associated protein 1 Antibody, Proline-rich synapse-associated protein 1 Antibody, ProSAP1 Antibody, SH3 and multiple ankyrin repeat domains protein 2 Antibody, SHAN2_RAT Antibody, SHANK Antibody, Shank2 Antibody, SPANK-3 Antibody

Size :

100 µg

Category :

Antibodies

Product Type :

Monoclonal

Clone Number :

S23b-49

Immunogen :

Fusion protein amino acids 84-309 of rat Shank2

Immunogen Species :

Rat

Swiss-Prot :

Q9QX74

Applications :

WB IHC IP ICC/IF AM

Host Species :

Mouse

Isotype :

IgG1

Species Reactivity Abbreviation :

Hu Ms Rt

Species Reactivity Full Name :

Human Mouse Rat

Antibody Dilution :

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Purification :

Protein G Purified

Storage Buffer :

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Concentration :

1 mg/ml

Specificity :

Detects ~160kDa. Recognizes Shank1, 2 and 3.

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SMC-327D, RRID: AB_2301756

Certificate of Analysis :

1 µg/ml of SMC-327 was sufficient for detection of Shank1-4 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Cellular Localization :

Cytoplasm Cell Junction Synapse Postsynaptic Cell Membrane Postsynaptic Density Cell Projection Growth Cone

Scientific Background :

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).

References :

1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856. 2. Kim J.H., et al. (2009) Exp Mol Med. 41(4): 236-242. 3. Gong Y., et al. (2009) Brain Res. 1292: 191-198.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SMC-327_SHANK-pan_Antibody_S23b-49_ICC-IF_Human_SK-N-BE-Cells-Human-Neuroblastoma-cells_60X_Composite_1.png SMC-327_SHANK_Antibody_S23b-49_WB_Rat_brain-membrane-lysate_1.png

more info or order :

StressMarq Biosciences product webpage