product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
KCNQ4 Antibody
catalog :
SMC-309D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S43-6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
StressMarq Biosciences product webpage
citations: 2
Reference
Wolter S, Möhrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, et al. GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing. Front Neural Circuits. 2018;12:65 pubmed publisher
Möhrle D, Reimann K, Wolter S, Wolters M, Varakina K, Mergia E, et al. NO-Sensitive Guanylate Cyclase Isoforms NO-GC1 and NO-GC2 Contribute to Noise-Induced Inner Hair Cell Synaptopathy. Mol Pharmacol. 2017;92:375-388 pubmed publisher
product information
Catalog No :
SMC-309D
Product Name :
KCNQ4 Antibody
Description :
Mouse Anti-Human KCNQ4 Monoclonal IgG1
Target :
KCNQ4
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Ion Channels Potassium Channels Voltage-Gated Potassium Channels Cancer
Alternative Name(s) :
DFNA 2 antibody, DFNA2 antibody, KCNQ 4 antibody, Kcnq4 antibody, KCNQ4_HUMAN antibody, KQT like 4 antibody, KQT-like 4 antibody, KV7.4 antibody, Potassium channel KQT like 4 antibody, Potassium channel subunit alpha KvLQT4 antibody, Potassium voltage gated channel KQT like protein 4 antibody, Potassium voltage gated channel KQT like subfamily member 4 antibody, Potassium voltage gated channel subfamily KQT member 4 antibody, Potassium voltage-gated channel subfamily KQT member 4 antibody, Voltage gated potassium channel subunit Kv7.4 antibody, Voltage-gated potassium channel subunit Kv7.4 antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S43-6
Immunogen :
Fusion protein amino acids 2-77 of human KCNQ4
Immunogen Species :
Human
Accession Number :
NP_004691.2
Swiss-Prot :
P56696
Applications :
WB IHC ICC/IF IP AM
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~77kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-309D, RRID: AB_2131718
Certificate of Analysis :
1 µg/ml of SMC-309 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Plasma Membrane Basal Cell Membrane
Scientific Background :
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).
References :
1. Hernandez C.C., Zaiko O., Tolstykh G.P., Shapiro M.S. (2008) J Physiol. 586(7): 1811-1821. 2. Kharkovets T., et al. (2006) EMBO J. 25(3): 642-652. 3. Tatulian L., Delmas P., Abogadie F.C., Brown D.A. (2001) J Neuroscience. 21(15): 5535-5545.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-309_KCNQ4_Antibody_S43-6_IHC_mouse_frozen-brain-section_1.png SMC-309_KCNQ4_Antibody_S43-6_WB_Rat_tissue-lysate_1.png SMC-309_KCNQ4_Antibody_S43-6_IHC_Human_hippocampus_1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.