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company name :
StressMarq Biosciences
product type :
antibody
product name :
GRP170 Antibody
catalog :
SMC-233D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6G7-2H5
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-233D
Product Name :
GRP170 Antibody
Description :
Mouse Anti-Human GRP170 Monoclonal IgG2aK
Target :
GRP170
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Cancer Heat Shock Neuroscience Neurodegeneration Epigenetics and Nuclear Signaling Cardiovascular System Cell Signaling Protein Trafficking Chaperone Proteins ER Proteins Cancer Invasion/microenvironment Cancer Cancer Metabolism Response to Hypoxia Cell Signaling Metabolism Metabolism processes Hypoxia
Alternative Name(s) :
ORP150 Antibody, HSP12A Antibody, Hypoxia up regulated 1 Antibody, Orp150 Antibody, Glucose regulated Antibody 170 Antibody, 150kDa oxygen regulated Antibody Antibody, 150 kDa oxygen regulated protein antibody, 150 kDa oxygen-regulated protein antibody, 170 kDa glucose regulated protein antibody, 170 kDa glucose-regulated protein antibody, DKFZp686N08236 antibody, FLJ94899 antibody, FLJ97572 antibody, glucose regulated protein 170 antibody, Grp 170 antibody, GRP-170 antibody, Grp170 antibody, HSP 12A antibody, HSP12A antibody, Hyou1 antibody, HYOU1_HUMAN antibody, Hypoxia up regulated 1 antibody, hypoxia up-regulated 1 precursor antibody, Hypoxia up-regulated protein 1 antibody, Hypoxia upregulated 1 antibody, Orp 150 antibody, ORP-150 antibody, Orp150 antibody, oxygen regulated protein (150kD) antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
6G7-2H5
Immunogen :
Raised against a synthetic peptide of human GRP170
Immunogen Species :
Human
Accession Number :
NP_006389.3
Swiss-Prot :
Q9Y4L1
Applications :
WB ICC/IF
Host Species :
Mouse
Isotype :
IgG2a
Species Reactivity Abbreviation :
Hu
Species Reactivity Full Name :
Human
Antibody Dilution :
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~170kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-233D, RRID: AB_2699484
Certificate of Analysis :
1 µg/ml of SMC-233 was sufficient for detection of GRP170 in 20 µg of HEK293 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Endoplasmic Reticulum Endoplasmic Reticulum Lumen
Scientific Background :
GRP170, also known as ORP150, is the largest member of glucose-regulated Antibodys, and acts as a human chaperone Antibody. It is thought to play an important role in Antibody folding and secretion in the ER. Suppression of the Antibody is associated with accelerated apoptosis, therefore having an important cryoprotective role in hypoxia-induced cellular pertubation. This cryopotective role has led to an anti-tumor immune response, which will hopefully lead to therapeutic immunizations against cancers (1). GRP170 has also been shown to bind with dendritic cells and provide the danger signals to induce anti-tumor immune responses (2).
References :
1. Wang H., et al. (2014) Front Oncol. 4: 377. 2. Manjili M.H., et al. (2006) Immun. Cell Biol. 84: 203-208.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-233-GRP170-Antibody-6G7-2H5-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-233-GRP170-Antibody-6G7-2H5-WB-Human-HEK-293-cell-lysate-1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.