product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
HSP47 Antibody
catalog :
SMC-203B
quantity :
200 µg
price :
330.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1C4-1A6
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-203B
Product Name :
HSP47 Antibody
Description :
Mouse Anti-Human HSP47 Monoclonal IgG1 Kappa
Target :
HSP47
Conjugate :
Unconjugated
2021 List Price :
330.00 USD
Currency :
USD
Research Area(s) :
Cancer Heat Shock Cell Signaling Protein Trafficking Chaperone Proteins
Alternative Name(s) :
SerpinH1 Antibody, Colligin Antibody, Gp46 Antibody, serine proteinase inhibitor Antibody, cysteine proteinase inhibitor Antibody, collagen binding protein Antibody
Size :
200 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
1C4-1A6
Immunogen :
Human HSP47, full length
Immunogen Species :
Human
Accession Number :
NP_001193943
Swiss-Prot :
P50454.2
Applications :
WB ICC/IF
Host Species :
Mouse
Isotype :
IgG1 Kappa
Species Reactivity Abbreviation :
Hu
Species Reactivity Full Name :
Human
Antibody Dilution :
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects 47kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-203B, RRID: AB_2699196
Certificate of Analysis :
1 µg/ml of SMC-203 was sufficient for detection of HSP47 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Endoplasmic Reticulum Endoplasmic Reticulum Lumen
Scientific Background :
HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1). The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).
References :
1. Razzaque MS., Taquchi T., (1999) Histol Histopathol. 14 (4): 1999-212. 2. Taguchi T., et al. (2011) Acta Histochem Cytochem. 44(2):35-41. 3. Nong Z., et al. (2011) Am J Pathol. 197(5): 2189-96.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-203_Hsp47_Antibody_1C4-1A6_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png SMC-203_Hsp47_Antibody_1C4-1A6_WB_Human_Epithelial-cell-A431-lysates_1.png SMC-203_Hsp47_Antibody_1C4-1A6_ICC-IF_Human_Heat-Shocked-HeLa-Cells_20x_Composite.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.