This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
StressMarq Biosciences
product type :
antibody
product name :
p53 Antibody
catalog :
SMC-183D
quantity :
100 µg
price :
242.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Pab 1801
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, flow cytometry, radioimmunoassay
product information
Catalog No :
SMC-183D
Product Name :
p53 Antibody
Description :
Mouse Anti-Human p53 Monoclonal IgG1
Target :
p53
Conjugate :
Unconjugated
2021 List Price :
242.00 USD
Currency :
USD
Research Area(s) :
Cancer Oxidative Stress Cancer Apoptosis Cell Signaling Epigenetics and Nuclear Signaling
Alternative Name(s) :
P53 Antibody, LFS1 Antibody, TRP53 Antibody, FLJ92943 Antibody, TP53 Antibody, p53 Tumor Suppressor Antibody, Phosphoprotein p53 Antibody, TP53 Antibody, Transformation related protein 53 Antibody, TRP53 Antibody, Tumor protein p53 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
Pab 1801
Immunogen :
Fusion protein (Human), amino acids 46-53
Immunogen Species :
Human
Accession Number :
NP_000537.3
Swiss-Prot :
P04637
Applications :
WB IHC IP ELISA RIA FCM
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu
Species Reactivity Full Name :
Human
Antibody Dilution :
WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~53kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-183D, RRID: AB_10639876
Certificate of Analysis :
1 µg/ml of SMC-183 was sufficient for detection of p53 in 10 µg of HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Cytoplasm Nucleus PML body Endoplasmic Reticulum
Scientific Background :
The p53 protein (tumor protein 53 or TP53) is a DNA-binding cell cycle-regulating transcription factor that governs cell division and the fine balance between cell death and cell survival (1). P53 plays a critical role in tumor suppression and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman." This also refers to its role in conserving stability by preventing genome mutation (2). Defects in p53 are linked to >50% of human cancers, and restoring p53 function to these cancer cells can induce growth arrest and apoptosis (3). When p53 has been damaged, it can also lead to autoimmune disorders (4, 5).
References :
1. Georescu C.V., Saftoiu A., Georgescu C.C., Ciurea R. and Ciurea T. (2007) J Gastrointestin Liver Dis. 16(2): 133-9. 2. Strachan T., et al. (1999) Human Molecular Genetics 2. Ch. 18: Cancer Genetics. 3. Hansen J.E., et al. (2007) Cancer Research 67: 1769-1774. 4. Di Cesare E., et al. (2001) Ann Clin Lab Sci 31: 253-8. 5. Akere A., Otegbayo J.A. (2007) Singapore Med J. 48(1): 41-4.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-183_p53_Antibody_Pab1801_WB_Human_HeLa-cell-lysates_1.png
SMC-183_p53_Antibody_Pab1801_IHC_Human_
esophagus-cancer-cells_1.png
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.