DNA/RNA Damage Antibody | StressMarq Biosciences SMC-155 product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

DNA/RNA Damage Antibody

catalog :

SMC-155

quantity :

25 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15A3

reactivity :

human

application :

ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

StressMarq Biosciences product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human	Aboud O, Mrak R, Boop F, Griffin W. Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype. Acta Neuropathol Commun. 2013;1:41 pubmed publisher
	Cheli V, Santiago González D, Wan Q, Denaroso G, Wan R, Rosenblum S, et al. H-ferritin expression in astrocytes is necessary for proper oligodendrocyte development and myelination. Glia. 2021;69:2981-2998 pubmed publisher
	Greenwald S, Brown E, Scandura M, Hennessey E, Farmer R, Du J, et al. Mutant Nmnat1 leads to a retina-specific decrease of NAD+ accompanied by increased poly(ADP-ribose) in a mouse model of NMNAT1-associated retinal degeneration. Hum Mol Genet. 2021;30:644-657 pubmed publisher
	Sule G, Abuaita B, Steffes P, Fernandes A, Estes S, Dobry C, et al. Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus. J Clin Invest. 2021;131: pubmed publisher
	Attri A, Thakur D, Kaur T, Sensale S, Peng Z, Kumar D, et al. Nanoparticles Incorporating a Fluorescence Turn-on Reporter for Real-Time Drug Release Monitoring, a Chemoenhancer and a Stealth Agent: Poseidon's Trident against Cancer?. Mol Pharm. 2021;18:124-147 pubmed publisher
	Bakewell S, Conde I, Fallah Y, McCoy M, Jin L, Shajahan Haq A. Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer. Cancers (Basel). 2020;12: pubmed publisher
	Wu P, Scarlata E, O Flaherty C. Long-Term Adverse Effects of Oxidative Stress on Rat Epididymis and Spermatozoa. Antioxidants (Basel). 2020;9: pubmed publisher
	Flis S, Bratek E, Chojnacki T, Piskorek M, Skorski T. Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells. Cancers (Basel). 2019;11: pubmed publisher
	Komakula S, Tumová J, Kumaraswamy D, Burchat N, Vartanian V, Ye H, et al. The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue. Sci Rep. 2018;8:14886 pubmed publisher
	Cui S, Lv X, Li W, Li Z, Liu H, Gao Y, et al. Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biol. 2018;19:81-91 pubmed publisher
	Amini P, Stojkov D, Felser A, Jackson C, Courage C, Schaller A, et al. Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production. Nat Commun. 2018;9:2958 pubmed publisher
	Lai J, Wang M, Huang C, Wu C, Hung L, Yang C, et al. Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells. EMBO Rep. 2018;19: pubmed publisher
	Alhadidi Q, Nash K, Alaqel S, Sayeed M, Shah Z. Cofilin Knockdown Attenuates Hemorrhagic Brain Injury-induced Oxidative Stress and Microglial Activation in Mice. Neuroscience. 2018;383:33-45 pubmed publisher
	Angeloni C, Teti G, Barbalace M, Malaguti M, Falconi M, Hrelia S. 17β-Estradiol enhances sulforaphane cardioprotection against oxidative stress. J Nutr Biochem. 2017;42:26-36 pubmed publisher
	Liu Y, O Flaherty C. In vivo oxidative stress alters thiol redox status of peroxiredoxin 1 and 6 and impairs rat sperm quality. Asian J Androl. 2017;19:73-79 pubmed publisher
	Lood C, Blanco L, Purmalek M, Carmona Rivera C, De Ravin S, Smith C, et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med. 2016;22:146-53 pubmed publisher
	Angeloni C, Malaguti M, Rizzo B, Barbalace M, Fabbri D, Hrelia S. Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity. Chem Res Toxicol. 2015;28:1234-45 pubmed publisher
	Ozkosem B, Feinstein S, Fisher A, O Flaherty C. Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice. Redox Biol. 2015;5:15-23 pubmed publisher
	Zawada W, Mrak R, Biedermann J, Palmer Q, Gentleman S, Aboud O, et al. Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation. Acta Neuropathol Commun. 2015;3:9 pubmed publisher
	Brennan L, Haukedal J, Earle J, Keddie B, Harris H. Disruption of redox homeostasis leads to oxidative DNA damage in spermatocytes of Wolbachia-infected Drosophila simulans. Insect Mol Biol. 2012;21:510-20 pubmed publisher

image

image 1 :

Immunohistochemistry analysis using Mouse Anti-DNA Damage Monoclonal Antibody, Clone 15A3 (SMC-155). Tissue: Retinal Injury Model. Species: Mouse. Primary Antibody: Mouse Anti-DNA Damage Monoclonal Antibody (SMC-155) at 1:1000. Secondary Antibody: Alexa Fluor 594 Goat Anti-Mouse (red). Courtesy of: Dr. Rajashekhar Gangaraju, University of Indiana, Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute.

product information

Catalog No :

SMC-155

Product Name :

DNA/RNA Damage Antibody

Description :

Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

Target :

DNA Damage

Research Area(s) :

Cancer Oxidative Stress Cell Signaling Post-translational Modifications Oxidation Cell Signaling Epigenetics and Nuclear Signaling DNA/RNA DNA Damage and Repair

Alternative Name(s) :

8-Hydroxy Guanine Antibody, 8-OH-dG Antibody, 8OHG Antibody, 80G Antibody, 8 hydroxyguanine Antibody, 8 hydroxy 2' deoxyguanosine Antibody, 8 hydroxyguanosine Antibody, 8 OHG Antibody, 8-OHG Antibody, 8OHdG Antibody

Category :

Antibodies

Product Type :

Monoclonal

Clone Number :

15A3

Immunogen :

8-hydroxy-guanosine-BSA and –casein conjugates

Applications :

IHC ICC/IF ELISA DB IP FCM FA

Host Species :

Mouse

Isotype :

IgG2b

Species Reactivity Medium :

Species Independent

Antibody Dilution :

IHC (1:1000); optimal dilutions for assays should be determined by the user.

Purification :

Protein G Purified

Specificity :

Recognizes markers of oxidative damage to DNA (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine).

Size 1 :

25 µg

Size 2 :

100 µg

more info or order :

StressMarq Biosciences product webpage