product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
HSP90 alpha/beta Antibody
catalog :
SMC-135
quantity :
25 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Hyb-K41220A
reactivity :
human, mouse, rat, brewer's yeast
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
citations: 5
Published Application/Species/Sample/DilutionReference
  • western blot; brewer's yeast
Horvat N, Armstrong H, Lee B, Mercier R, Wolmarans A, Knowles J, et al. A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p. J Mol Biol. 2014;426:2379-92 pubmed publisher
Hirata C, Ito S, Masutani H. Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes. Arch Biochem Biophys. 2019;677:108159 pubmed publisher
Mercier R, Wolmarans A, Schubert J, Neuweiler H, Johnson J, LaPointe P. The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation. Nat Commun. 2019;10:1273 pubmed publisher
Perić M, Bou Dib P, Dennerlein S, Musa M, Rudan M, Lovrić A, et al. Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan. Sci Rep. 2016;6:28751 pubmed publisher
Stasyk T, Holzmann J, Stumberger S, Ebner H, Hess M, Bonn G, et al. Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts. Proteomics. 2010;10:4117-27 pubmed publisher
image
image 1 :
StressMarq Biosciences SMC-135 image 1
Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Hsp90 alpha/beta Monoclonal Antibody, Clone K41220A (SMC-135). Tissue: Cervical cancer cell line (HeLa). Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Mouse Anti-Hsp90 alpha/beta Monoclonal Antibody (SMC-135) at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Melanosome. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp90 alpha/beta Antibody. (C) Composite.
product information
Catalog No :
SMC-135
Product Name :
HSP90 alpha/beta Antibody
Description :
Mouse Anti-Human HSP90 alpha/beta Monoclonal IgG2a
Target :
HSP90 alpha/Beta
Research Area(s) :
Cancer Heat Shock Cell Signaling Protein Trafficking Chaperone Proteins Cancer Tumor Biomarkers
Alternative Name(s) :
HSP86 Antibody, HSP89A Antibody, HSP90AA1 Antibody, HSP90Alpha Antibody, HSPC1 Antibody, HSPCA Antibody, HSPCAL3 Antibody, HSP84 Antibody, HSP90B Antibody, HSPC2 Antibody, HSPCB Antibody, D6S182 Antibody, FLJ26984 Antibody
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
Hyb-K41220A
Immunogen :
Recombinant human HSP90alpha; Specificity mapped to amino acids 291-304
Accession Number :
NP_031381.2, NP_001017963.2
Swiss-Prot :
P08238, P07900
Applications :
WB IHC ICC/IF ELISA
Host Species :
Mouse
Isotype :
IgG2a
Species Reactivity Medium :
Human Mouse Rat Yeast
Antibody Dilution :
WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Specificity :
Detects 90kDa. Will detect both alpha (inducible) and beta (constitutively-expressed) forms.
Cellular Localization :
Cytoplasm Melanosome
Size 1 :
25 µg
Size 2 :
100 µg
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.