HSP90 Antibody | StressMarq Biosciences SMC-107 product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

HSP90 Antibody

catalog :

SMC-107

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H9010

reactivity :

human, mouse, rat, dogs, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

StressMarq Biosciences product webpage

citations: 30

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5b, 6c	Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher
immunohistochemistry; human; 1:500; loading ...; fig 3b	Rodina A, Wang T, Yan P, Gomes E, Dunphy M, Pillarsetty N, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016;538:397-401 pubmed publisher
western blot; human; fig 1	Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, YING Q, et al. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90Î±) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016;6:20605 pubmed publisher
western blot; human	Hunter M, O Hagan K, Kenyon A, Dhanani K, Prinsloo E, Edkins A. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PLoS ONE. 2014;9:e86842 pubmed publisher
western blot; human; 1:2500	Patel P, Yan P, Seidler P, Patel H, Sun W, Yang C, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013;9:677-84 pubmed publisher
western blot; human; 1:2000	Taldone T, Zatorska D, Patel P, Zong H, Rodina A, Ahn J, et al. Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg Med Chem. 2011;19:2603-14 pubmed publisher
western blot; human; 1:4000	Gershburg S, Murphy L, Marschall M, Gershburg E. Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization. Biochem J. 2010;431:227-35 pubmed publisher
	Joshi S, Gomes E, Wang T, Corben A, Taldone T, Gandu S, et al. Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer. Commun Biol. 2021;4:1333 pubmed publisher
	Bolaender A, Zatorska D, He H, Joshi S, Sharma S, Digwal C, et al. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun. 2021;12:4669 pubmed publisher
	Mediani L, Antoniani F, Galli V, Vinet J, Carrá A, Bigi I, et al. Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling. EMBO Rep. 2021;22:e51740 pubmed publisher
	Saxena A, Walters M, Shieh J, Shen L, Gomi K, Downey R, et al. Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells. Sci Rep. 2021;11:6104 pubmed publisher
	Lv K, Gong C, Antony C, Han X, Ren J, Donaghy R, et al. HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell. 2021;28:1275-1290.e9 pubmed publisher
	Yan P, Patel H, Sharma S, Corben A, Wang T, Panchal P, et al. Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell Rep. 2020;31:107840 pubmed publisher
	Pillarsetty N, Jhaveri K, Taldone T, Caldas Lopes E, Punzalan B, Joshi S, et al. Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Cancer Cell. 2019;36:559-573.e7 pubmed publisher
	Tang X, Chang C, Guo J, Lincoln V, Liang C, Chen M, et al. Tumour-Secreted Hsp90α on External Surface of Exosomes Mediates Tumour - Stromal Cell Communication via Autocrine and Paracrine Mechanisms. Sci Rep. 2019;9:15108 pubmed publisher
	Garcia Silva S, Benito Martin A, Sánchez Redondo S, Hernández Barranco A, Ximénez Embún P, Nogués L, et al. Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation. J Exp Med. 2019;216:1061-1070 pubmed publisher
	Kishinevsky S, Wang T, Rodina A, Chung S, Xu C, Philip J, et al. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nat Commun. 2018;9:4345 pubmed publisher
	Peksel B, Gombos I, Peter M, Tiszlavicz Á, Brameshuber M, Balogh G, et al. Mild heat induces a distinct "eustress" response in Chinese Hamster Ovary cells but does not induce heat shock protein synthesis. Sci Rep. 2017;7:15643 pubmed publisher
	Guo J, Jayaprakash P, Dan J, Wise P, Jang G, Liang C, et al. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017;37: pubmed publisher
	Dong H, Le Y, Wang Y, Zhao H, Huang C, Hu Y, et al. Extracellular heat shock protein 90? mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling. Respir Res. 2017;18:111 pubmed publisher
	de la Mare J, Jurgens T, Edkins A. Extracellular Hsp90 and TGFÎ² regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC Cancer. 2017;17:202 pubmed publisher
	Matsuzaka Y, Tanihata J, Komaki H, Ishiyama A, Oya Y, Ruegg U, et al. Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice. PLoS ONE. 2016;11:e0167811 pubmed publisher
	Zou M, Bhatia A, Dong H, Jayaprakash P, Guo J, Sahu D, et al. Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene. 2017;36:2160-2171 pubmed publisher
	Tunnah L, MacKellar S, Barnett D, MacCormack T, Stehfest K, Morash A, et al. Physiological responses to hypersalinity correspond to nursery ground usage in two inshore shark species (Mustelus antarcticus and Galeorhinus galeus). J Exp Biol. 2016;219:2028-38 pubmed publisher
	Goldstein R, Yang S, Taldone T, Chang B, Gerecitano J, Elenitoba Johnson K, et al. Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma. J Clin Invest. 2015;125:4559-71 pubmed publisher
	Teigen L, Orczewska J, McLaughlin J, O Brien K. Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback. Comp Biochem Physiol A Mol Integr Physiol. 2015;188:139-47 pubmed publisher
	Jayaprakash P, Dong H, Zou M, Bhatia A, O Brien K, Chen M, et al. Hsp90Î± and Hsp90Î² together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci. 2015;128:1475-80 pubmed publisher
	Bessemer R, Butler K, Tunnah L, Callaghan N, Rundle A, Currie S, et al. Cardiorespiratory toxicity of environmentally relevant zinc oxide nanoparticles in the freshwater fish Catostomus commersonii. Nanotoxicology. 2015;9:861-70 pubmed publisher
	Espallergues J, Teegarden S, Veerakumar A, Boulden J, Challis C, Jochems J, et al. HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. J Neurosci. 2012;32:4400-16 pubmed publisher
	Chen Q, Prior M, Dargusch R, Roberts A, Riek R, Eichmann C, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS ONE. 2011;6:e27865 pubmed publisher

image

image 1 :

Immunohistochemistry analysis using Mouse Anti-Hsp90 Monoclonal Antibody, Clone H9010 (SMC-107). Tissue: inflamed colon. Species: Mouse. Fixation: Formalin. Primary Antibody: Mouse Anti-Hsp90 Monoclonal Antibody (SMC-107) at 1:10000 for 12 hours at 4°C. Secondary Antibody: Alexa Fluor 555 Goat Anti-Mouse (red) at 1:5000 for 1 hour at RT. Localization: Inflammatory and epithelial mucosa. Magnification: 40x. Inflammatory and epithelial mucosa. This image was produced using an amplifying IHC wash buffer. The antibody has therefore been diluted more than is recommended for other applications.

product information

Catalog No :

SMC-107

Product Name :

HSP90 Antibody

Description :

Mouse Anti-Human HSP90 Monoclonal IgG2a

Target :

HSP90

Research Area(s) :

Cancer Heat Shock Cell Signaling Protein Trafficking Chaperone Proteins Cancer Tumor Biomarkers

Alternative Name(s) :

HSP84 Antibody, HSP90 Antibody, HSP90 beta Antibody, HSP90B Antibody, HSPC2 Antibody, HSPCB Antibody

Category :

Antibodies

Product Type :

Monoclonal

Clone Number :

H9010

Immunogen :

Recombinant human HSP90beta

Accession Number :

NP_031381.2

Swiss-Prot :

P08238

Applications :

WB IHC ICC/IF IP ELISA AM

Host Species :

Mouse

Isotype :

IgG2a

Species Reactivity Medium :

Human Mouse Rat Rabbit Chicken Dog Fish Shark Hamster

Antibody Dilution :

WB (1:2500), IHC (1:100); optimal dilutions for assays should be determined by the user.

Purification :

Protein G Purified

Specificity :

Detects 90kDa. Detects HSP90 beta in all reactive species except in Chicken, where it detects both alpha and beta isoforms.

Cellular Localization :

Cytoplasm Melanosome

Size 1 :

50 µg

Size 2 :

200 µg

more info or order :

StressMarq Biosciences product webpage