HSP70/HSC70 Antibody | StressMarq Biosciences SMC-106 product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

HSP70/HSC70 Antibody

catalog :

SMC-106

quantity :

200 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BB70

reactivity :

human, mouse, rat, dogs, chicken, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

StressMarq Biosciences product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human	Taldone T, Kang Y, Patel H, Patel M, Patel P, Rodina A, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014;57:1208-24 pubmed publisher
western blot; human	Kang Y, Taldone T, Patel H, Patel P, Rodina A, Gozman A, et al. Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014;57:1188-207 pubmed publisher
	Poliacikova G, Barthez M, Rival T, Aouane A, Luis N, Richard F, et al. M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development. Nat Commun. 2023;14:3187 pubmed publisher
	Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher
	Guilbert S, Lambert H, Rodrigue M, Fuchs M, Landry J, Lavoie J. HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency. FASEB J. 2018;32:3518-3535 pubmed publisher
	Rodina A, Taldone T, Kang Y, Patel P, Koren J, Yan P, et al. Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. ACS Chem Biol. 2014;9:1698-705 pubmed publisher
	Rodina A, Patel P, Kang Y, Patel Y, Baaklini I, Wong M, et al. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chem Biol. 2013;20:1469-80 pubmed publisher

image

image 1 :

Immunohistochemistry analysis using Mouse Anti-Hsp70 Monoclonal Antibody, Clone BB70 (SMC-106). Tissue: inflamed colon. Species: Mouse. Fixation: Formalin. Primary Antibody: Mouse Anti-Hsp70 Monoclonal Antibody (SMC-106) at 1:10000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Mouse at 1:2000 for 1 hour at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 200 µl for 2 minutes at RT. Localization: Inflammatory cells. Magnification: 40x. Inflammatory cells. HSP70/HSC70 stained brown. This image was produced using an amplifying IHC wash buffer. The antibody has therefore been diluted more than is recommended for other applications.

product information

Parent Catalog No. :

SMC-106

Catalog No :

SMC-106

Product Name :

HSP70/HSC70 Antibody

Description :

Mouse Anti-Chicken HSP70/HSC70 Monoclonal IgG2a

Target :

HSP70/HSC70

Conjugate :

Unconjugated

Size 1 :

200 µg

Size 2 :

50 µg

Research Area(s) :

Cell Signaling Protein Trafficking Chaperone Proteins Cancer Tumor Biomarkers Cancer Heat Shock

Alternative Name(s) :

HSC54 Antibody, HSC70 Antibody, HSC71 Antibody, HSP70 1 Antibody, HSP701/HSP70 2 Antibody, HSP70.1 Antibody, HSP71 Antibody, HSP72 Antibody, HSP73 Antibody, HSPA1 Antibody, HSPA10 Antibody, HSPA1A Antibody, HSPA1B Antibody, LAP1 Antibody, NIP71 Antibody

Product Type :

Monoclonal

Clone Number :

BB70

Immunogen :

Chicken HSP70/HSP90 complex

Immunogen Species :

Chicken

Accession Number :

NP_001006686.1

Swiss-Prot :

P08106

Applications :

WB ICC/IF IHC IP

Host Species :

Mouse

Isotype :

IgG2a

Species Reactivity Medium :

Human Mouse Rat Bovine Sheep Dog Beluga Fish Guinea Pig Pig Hamster Rabbit Chicken Xenopus Drosophila Yeast

Purification :

Protein G Purified

Concentration :

1 mg/ml

Specificity :

Detects ~72 (HSP) and ~73kDa (HSC).

Cellular Localization :

Cytoplasm

Image Filenames :

SMC-106_Hsp70_Antibody_BB70_IHC_Human_colon-carcinoma_40x_1.png SMC-106_Hsp70_Antibody_BB70_WB_Bovine_MDBK-cell-lysates_1.png SMC-106_Hsp70_Antibody_BB70_ICC-IF_Rat_hepatocyte-nuclei_1.png SMC-106_Hsp70_Antibody_BB70_WB_Human_HeLa-cell-lysates_1.png SMC-106_Hsp70_Antibody_BB70_IHC_Rat_hepatocytes_1.png
SMC-106_Hsp70_Antibody_BB70_IHC_Mouse_i
nflamed-colon_40x_1.png

more info or order :

StressMarq Biosciences product webpage