Anti-Active Caspase-3 antibody | St John's Laboratory STJ97448 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Active Caspase-3 antibody

catalog :

STJ97448

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5E1

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5e	Li D, Chen J, Guo J, Li L, Cai G, Chen S, et al. A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression. elife. 2021;10: pubmed publisher

product information

Catalog Number :

STJ97448

Product Name :

Anti-Active Caspase-3 antibody

Product Type :

Primary Antibody

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Unconjugated

Clone Name :

5E1

Isotype :

IgG1

Size :

100μl

Product Description :

Active caspase-3 is a protein encoded by the CASP3 gene which is approximately 31,6 kDa. Active caspase-3 is localised to the cytoplasm. It is involved in the TNFR1 pathway, apoptosis modulation and signalling and respiratory electron transport. This protein falls under the cysteine-aspartic acid protease family. It is a sequential activator of caspases and plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Active caspase-3 is highly expressed in lung, spleen, heart, liver and kidney. Mutations in the CASP3 gene may result in bladder urothelial carcinoma and primary effusion lymphoma. STJ97448 was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous active caspase-3 protein.

CrossReactivity :

Human, Mouse, Rat, Chicken

ALTnames :

CASP3 antibody, CPP32 antibody, Caspase-3 antibody, CASP-3 antibody, Apopain antibody, Cysteine protease CPP32 antibody, CPP-32 antibody, Protein Yama antibody, SREBP cleavage activity 1 antibody, SCA-1 antibody, Caspase-3 subunit p17 antibody, Caspase-3 subunit p12 antibody

Immunogen :

Recombinant Protein

Localization :

Cytoplasm

Specificity :

The antibody detects endogenous Active Caspase-3 protein.

Purity :

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Application Summary :

WB, IHC-p, IF

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage