Anti-Neu antibody | St John's Laboratory STJ94412 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Neu antibody

catalog :

STJ94412

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western Blot (WB) analysis of specific cells using Neu Polyclonal Antibody.

product information

Catalog Number :

STJ94412

Product Name :

Anti-Neu antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Neu is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. Neu isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the nucleus and cytoplasm. It is involved in RET signalling, the GPCR pathway, signalling by ERBB2 and glioma. It is a protein tyrosine kinase that is part of several cell surface receptor complexes. It has no ligand binding domain of its own and therefore cannot bind growth factors. It however does bind to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways. Neu is expressed in a variety of tumor tissues including primary breast tumors. Mutations in the ERBB2 gene may result in lung cancer and ovarian cancer. STJ94412 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neu protein.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

ERBB2 antibody, HER2 antibody, MLN19 antibody, NEU antibody, NGL antibody, Receptor tyrosine-protein kinase erbB-2 antibody, Metastatic lymph node gene 19 protein antibody, MLN 19 antibody, Proto-oncogene Neu antibody, Proto-oncogene c-ErbB-2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, p185erbB2 antibody, CD antigen CD340 antibody

Immunogen :

Synthesized peptide derived from human Neu

Epitope :

610-690 aa, Internal

Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.

Specificity :

Neu Polyclonal Antibody detects endogenous levels of Neu protein.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, IF, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage