Anti-Myotubularin antibody | St John's Laboratory STJ94317 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Myotubularin antibody

catalog :

STJ94317

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western Blot (WB) analysis of specific cells using Myotubularin Polyclonal Antibody.

product information

Catalog Number :

STJ94317

Product Name :

Anti-Myotubularin antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Myotubularin is a protein encoded by the MTM1 gene which is approximately 69,9 kDa. Myotubularin is localised to the cytoplasm and cell membrane. It is involved in PI metabolism, inositol phosphate metabolism and glycerophospholipid biosynthesis. It negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. It also plays a role in mitochondrial morphology and positioning and is required for skeletal muscle maintenance. Myotubularin is expressed in the blood, nervous system and muscle. Mutations in the MTM1 gene may result in X-linked myopathy and Charcot-Marie-tooth disease. STJ94317 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Myotubularin protein.

CrossReactivity :

Human, Mouse

ALTnames :

MTM1 antibody, CG2 antibody, Myotubularin antibody, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase antibody, Phosphatidylinositol-3-phosphate phosphatase antibody

Immunogen :

Synthesized peptide derived from human Myotubularin.

Epitope :

Internal

Localization :

Cytoplasm Cell membrane; Peripheral membrane protein Cell projection, filopodium Cell projection, ruffle Late endosome Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation.

Specificity :

Myotubularin Polyclonal Antibody detects endogenous levels of Myotubularin protein.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage