Anti-Lamin A/C antibody | St John's Laboratory STJ93885 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Lamin A/C antibody

catalog :

STJ93885

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western blot (WB) analysis of Lamin A/C Polyclonal Antibody.

product information

Catalog Number :

STJ93885

Product Name :

Anti-Lamin A/C antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Lamin A/C is a protein encoded by the LMNA gene which is approximately 74,1 kDa. Lamin A/C is localised to the nucleus and nuclear envelope. It is involved in the apoptosis and survival caspase cascade, mitotic cell cycle, unfolded protein response and arrhythmogenic right ventricular cardiomyopathy. It plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics and is required for normal development of the peripheral nervous system and skeletal muscle. It is also required for osteoblasto genesis and bone formation. Lamin A/C is expressed in the arteries. Mutations in the LMNA gene can result in Emery-Dreifuss muscular dystrophy 2. The antibody STJ93885 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at S392.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

LMNA antibody, LMN1 antibody, Prelamin-A/C antibody, Lamin-A/C antibody, 70 kDa lamin antibody, Renal carcinoma antigen NY-REN-32 antibody

Immunogen :

Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of S392.

Epitope :

330-410 aa

Localization :

Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; Isoform C: Nucleus speckle

Specificity :

Lamin A/C Polyclonal Antibody detects endogenous levels of Lamin A/C protein.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, IF, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage