Anti-FAS-L antibody | St John's Laboratory STJ93042 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-FAS-L antibody

catalog :

STJ93042

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western blot (WB) analysis of FAS-L Polyclonal Antibody.

product information

Catalog Number :

STJ93042

Product Name :

Anti-FAS-L antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

FAS-L is a protein encoded by the FASLG gene which is approximately 31,4 kDa. FAS-L is localised to the cell membrane and is involved in PEDF induced signalling, dimerization of procaspase-8, apoptosis modulation and signalling and the TNFR1 pathway. FAS-L is a member of the tumor necrosis factor superfamily. It is a cytokine that binds to TNFRSF6/FAS which is a receptor that transduces the apoptotic signal into cells. It may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. FAS-L is expressed in the blood, spleen, lymph nodes, intestine and kidney. Mutations in the FASLG gene result in autoimmune lymphoproliferative syndrome 1B. STJ93042 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FAS-L protein.

CrossReactivity :

Human, Mouse

ALTnames :

FASLG antibody, APT1LG1 antibody, CD95L antibody, FASL antibody, TNFSF6 antibody, Tumor necrosis factor ligand superfamily member 6 antibody, Apoptosis antigen ligand antibody, APTL antibody, CD95 ligand antibody, CD95-L antibody, Fas antigen ligand antibody, Fas ligand antibody, FasL antibody, CD antigen CD178 antibody, Tumor necrosis factor ligand superfamily member 6, membrane form antibody, Tumor necrosis factor ligand superfamily member 6, soluble form antibody, Receptor-binding FasL ectodomain antibody, Soluble Fas ligand antibody, sFasL antibody, ADAM10-processed FasL form antibody, APL antibody, FasL intracellular domain antibody, FasL ICD antibody, SPPL2A-processed FasL form antibody, SPA antibody

Immunogen :

Synthesized peptide derived from human FAS-L

Epitope :

70-150 aa, Internal

Localization :

Cell membrane Cytoplasmic vesicle lumen Lysosome lumen Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination . Colocalizes with the SPPL2A protease at the cell membrane . ; Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted Note=May be released into the extracellular fluid by cleavage from the cell surface. ; FasL intracellular domain: Nucleus Note=The FasL ICD cytoplasmic form is translocated into the nucleus.

Specificity :

FAS-L Polyclonal Antibody detects endogenous levels of FAS-L protein.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, IF, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage