Anti-DRP1 antibody | St John's Laboratory STJ92779 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-DRP1 antibody

catalog :

STJ92779

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western blot (WB) analysis of DRP1 Polyclonal Antibody.

product information

Catalog Number :

STJ92779

Product Name :

Anti-DRP1 antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

DRP1 is a protein encoded by the DNM1L gene which is approximately 81,8 kDa. DRP1 is localised to the cytoplasm and Golgi apparatus. It is involved in toll-like receptor signalling pathways, the TNF signalling pathway, cytoskeletal signalling and apoptotic cleavage of cellular proteins. This protein falls under the dynamin superfamily of GTPases. It mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. DRP1 is expressed ubiquitously with the highest levels found in skeletal muscles, heart, kidney and brain. Mutations in the DNM1L gene may result in encephalopathy. STJ92779 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of DRP1 protein.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

DNM1L antibody, DLP1 antibody, DRP1 antibody, Dynamin-1-like protein antibody, Dnm1p/Vps1p-like protein antibody, DVLP antibody, Dynamin family member proline-rich carboxyl-terminal domain less antibody, Dymple antibody, Dynamin-like protein antibody, Dynamin-like protein 4 antibody, Dynamin-like protein IV antibody, HdynIV antibody, Dynamin-related protein 1 antibody

Immunogen :

Synthesized peptide derived from human DRP1 around the non-phosphorylation site of S637.

Epitope :

580-660 aa

Localization :

Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Binds to phospholipid membranes.

Specificity :

DRP1 Polyclonal Antibody detects endogenous levels of DRP1 protein.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage