Anti-Cbl antibody | St John's Laboratory STJ92057 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Cbl antibody

catalog :

STJ92057

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western Blot (WB) analysis of specific cells using Cbl Polyclonal Antibody.

product information

Catalog Number :

STJ92057

Product Name :

Anti-Cbl antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Cbl is a protein encoded by the CBL gene which is approximately 99,6 kDa. Cbl is localised to the cytoplasm and cell membrane. It is involved in negative regulation of FGFR1 signalling, signalling by EGFR in cancer and the T cell receptor signalling pathway. It is an adapter protein that functions as a negative regulator of many signalling pathways that are triggered by activation of cell surface receptors. It accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Cbl is expressed in blood and cells of the nervous system. Mutations in the CBL gene may result in a Noonan syndrome-like disorder. STJ92057 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cbl protein.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

CBL antibody, CBL2 antibody, RNF55 antibody, E3 ubiquitin-protein ligase CBL antibody, Casitas B-lineage lymphoma proto-oncogene antibody, Proto-oncogene c-Cbl antibody, RING finger protein 55 antibody, RING-type E3 ubiquitin transferase CBL antibody, Signal transduction protein CBL antibody

Immunogen :

Synthesized peptide derived from human Cbl around the non-phosphorylation site of Y674.

Epitope :

610-690 aa

Localization :

Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Specificity :

Cbl Polyclonal Antibody detects endogenous levels of Cbl protein.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage