product summary
company name :
St John's Laboratory
product type :
antibody
product name :
Anti-Caspase-4 antibody
catalog :
STJ92022
quantity :
100μl
price :
150 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry - paraffin section
more info or order :
St John's Laboratory product webpage
product information
Catalog Number :
STJ92022
Product Name :
Anti-Caspase-4 antibody
Product Type :
Primary Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Isotype :
IgG
Size :
100μl
List Price :
150 USD
Product Description :
Caspase-4 is a protein encoded by the CASP4 gene which is approximately 43,2 kDa. Caspase-4 is localised to the cytoplasm, cytosol and endoplasmic reticulum membrane. It is involved in the p53 signalling, the TRAF pathway, ceramide pathway and innate immune system. CASP4 is an essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation. It is involved in the signalling pathways of apoptosis, necrosis and inflammation. It is widely expressed, including keratinocytes and colonic and small intestinal epithelial cells. Mutations in the CASP4 gene may result in neuroblastoma. STJ92022 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-4 protein.
CrossReactivity :
Human, Mouse, Rat
ALTnames :
CASP4 antibody, ICH2 antibody, Caspase-4 antibody, CASP-4 antibody, ICE and Ced-3 homolog 2 antibody, ICH-2 antibody, ICE antibody, rel-II antibody, Mih1 antibody, Protease TX antibody, Caspase-4 subunit 1 antibody, Caspase-4 subunit 2 antibody
Immunogen :
Synthesized peptide derived from human Caspase-4.
Epitope :
Internal
Localization :
Cytoplasm, cytosol Endoplasmic reticulum membrane Mitochondrion Inflammasome Secreted Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 . Released in the extracellular milieu by keratinocytes following UVB irradiation .
Specificity :
Caspase-4 Polyclonal Antibody detects endogenous levels of Caspase-4 protein.
Purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer :
Liquid in PBS containing 50% glycerol, 0.5% BSA
Preservative :
0.02% sodium azide
Concentration :
1 mg/ml
Application Summary :
WB, IHC-p, ELISA
Storage :
Store at -20°C, and avoid repeat freeze-thaw cycles.
more info or order :
St John's Laboratory product webpage
company information
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
+44 (0)2072322321
headquarters: UK