Anti-Phospho-IRF-3 (S385) antibody | St John's Laboratory STJ91040 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Phospho-IRF-3 (S385) antibody

catalog :

STJ91040

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western Blot (WB) analysis of 293 cells using Phospho-IRF-3 (S385) Polyclonal Antibody.

product information

Catalog Number :

STJ91040

Product Name :

Anti-Phospho-IRF-3 (S385) antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

phosphorylated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

IRF-3 is a protein encoded by the IRF3 gene which is approximately 47,2 kDa. IRF-3 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling and toll-like receptor signalling pathway. This protein falls under the interferon regulatory transcription factor family. It is found in an inactive form in the cytoplasm that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex is then translocated to the nucleus where it activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. IRF-3 is expressed constitutively in a variety of tissues. Mutations in the IRF3 gene may be involved in herpes simplex encephalitis. STJ91040 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous IRF-3 protein which only binds about S385 when S385 is phosphorylated.

CrossReactivity :

Human

ALTnames :

IRF3 antibody, Interferon regulatory factor 3 antibody, IRF-3 antibody, Phospho-IRF-3 (S385) antibody

Immunogen :

Synthesized peptide derived from human IRF-3 around the phosphorylation site of S385.

Epitope :

320-400 aa

Localization :

Cytoplasm Nucleus Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Specificity :

Phospho-IRF-3 (S385) Polyclonal Antibody detects endogenous levels of IRF-3 protein only when phosphorylated at S385.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, IF, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage