Anti-Phospho-Trk C (Y516) antibody | St John's Laboratory STJ90960 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Phospho-Trk C (Y516) antibody

catalog :

STJ90960

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western Blot (WB) analysis of HeLa cells using Phospho-Trk C (Y516) Polyclonal Antibody.

product information

Catalog Number :

STJ90960

Product Name :

Anti-Phospho-Trk C (Y516) antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

phosphorylated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Trk C is a protein encoded by the NTRK3 gene which is approximately 94,4 kDa. Trk C is localised to the cell membrane and is involved in apoptotic pathways in synovial fibroblasts, GPCR pathway, ERK signalling and apoptosis pathways. This protein falls under the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Trk C is widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain. Mutations in the NTRK3 gene are associated with susceptibility to congenital heart defects and differentiated thyroid carcinoma. STJ90960 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This primary antibody specifically binds to endogenous Trk C protein which only binds about Y516 when Y516 is phosphorylated.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

NTRK3 antibody, TRKC antibody, NT-3 growth factor receptor antibody, GP145-TrkC antibody, Trk-C antibody, Neurotrophic tyrosine kinase receptor type 3 antibody, TrkC tyrosine kinase antibody, Phospho-Trk C (Y516) antibody

Immunogen :

Synthesized peptide derived from human Trk C around the phosphorylation site of Y516.

Epitope :

460-540 aa

Localization :

Membrane; Single-pass type I membrane protein.

Specificity :

Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, ELISA, ICC

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage