Anti-Phospho-c-Abl (Y245) antibody | St John's Laboratory STJ90694 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Phospho-c-Abl (Y245) antibody

catalog :

STJ90694

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

St John's Laboratory product webpage

product information

Catalog Number :

STJ90694

Product Name :

Anti-Phospho-c-Abl (Y245) antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

phosphorylated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

c-Abl is a protein encoded by the ABL1 gene which is approximately 122,8 kDa. c-Abl is localised to the cytoplasm, nucleus and mitochondrion. It is involved in DNA double-strand break repair, development Slit-Robo signalling, cell cycle and the ErbB signalling pathway. It coordinates actin re-modelling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like branch formation, membrane anchoring, signalling and microtubule-binding proteins. c-Abl is widely expressed in human tissues. Mutations in the ABL1 gene result in chronic myeloid leukemia. STJ90694 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous c-Abl protein which only binds about Y245 when Y245 is phosphorylated.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

ABL1 antibody, ABL antibody, JTK7 antibody, Tyrosine-protein kinase ABL1 antibody, Abelson murine leukemia viral oncogene homolog 1 antibody, Abelson tyrosine-protein kinase 1 antibody, Proto-oncogene c-Abl antibody, p150 antibody, Phospho-c-Abl (Y245) antibody

Immunogen :

Synthesized peptide derived from human c-Abl around the phosphorylation site of Y245.

Epitope :

170-250 aa

Localization :

Cytoplasm, cytoskeleton. Nucleus. Mitochondrion Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). ; Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear.

Specificity :

Phospho-c-Abl (Y245) Polyclonal Antibody detects endogenous levels of c-Abl protein only when phosphorylated at Y245.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IF, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage