product summary
company name :
St John's Laboratory
product type :
antibody
product name :
Anti-Phospho-E2F-1 (T433) antibody
catalog :
STJ90458
quantity :
100μl
price :
150 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human
application :
western blot, ELISA
more info or order :
St John's Laboratory product webpage
product information
Catalog Number :
STJ90458
Product Name :
Anti-Phospho-E2F-1 (T433) antibody
Product Type :
Primary Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Antigen Modification :
phosphorylated
Isotype :
IgG
Size :
100μl
List Price :
150 USD
Product Description :
E2F-1 is a protein encoded by the E2F1 gene which is approximately 46,9 kDa. E2F-1 is localised to the nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, glioma, E2F mediated regulation of DNA replication and activation of BH3-only proteins. It is a transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. E2F-1 is expressed in the skin, pancreas and nervous system. Mutations in the E2F1 gene may result in retinoblastoma and pharyngoconjunctival fever. STJ90458 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous E2F-1 protein which only binds about T433 when T433 is phosphorylated.
CrossReactivity :
Human, Mouse
ALTnames :
E2F1 antibody, RBBP3 antibody, Transcription factor E2F1 antibody, E2F-1 antibody, PBR3 antibody, Retinoblastoma-associated protein 1 antibody, RBAP-1 antibody, Retinoblastoma-binding protein 3 antibody, RBBP-3 antibody, pRB-binding protein E2F-1 antibody, Phospho-E2F-1 (T433) antibody
Immunogen :
Synthesized peptide derived from human E2F-1 around the phosphorylation site of T433.
Epitope :
370-450 aa
Localization :
Nucleus.
Specificity :
Phospho-E2F-1 (T433) Polyclonal Antibody detects endogenous levels of E2F-1 protein only when phosphorylated at T433.
Purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer :
Liquid in PBS containing 50% glycerol, 0.5% BSA
Preservative :
0.02% sodium azide
Concentration :
1 mg/ml
Application Summary :
WB, ELISA
Storage :
Store at -20°C, and avoid repeat freeze-thaw cycles.
more info or order :
St John's Laboratory product webpage
company information
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
+44 (0)2072322321
headquarters: UK