Anti-Phospho-Cofilin (S3) antibody | St John's Laboratory STJ90230 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Phospho-Cofilin (S3) antibody

catalog :

STJ90230

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western Blot (WB) analysis of COLO205 cells using Phospho-Cofilin (S3) Polyclonal Antibody.

product information

Catalog Number :

STJ90230

Product Name :

Anti-Phospho-Cofilin (S3) antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

phosphorylated

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Cofilin is a protein encoded by the JAK1 gene which is approximately 133,2 kDa. Cofilin is localised to the endomembrane system and is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, Th17 cell differentiation and IL27-mediated signalling events. It phosphorylates STAT proteins and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Cofilin is expressed at higher levels in primary colon tumor than normal colon tissue. Mutations in the JAK1 gene may result in mixed lacrimal gland cancer, t-cell prolymphocytic leukemia and chilblain lupus. The antibody STJ90230 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Cofilin protein which only binds about S3 when S3 is phosphorylated.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

CFL1 antibody, CFL antibody, Cofilin-1 antibody, 18 kDa phosphoprotein antibody, p18 antibody, Cofilin, non-muscle isoform antibody, Phospho-Cofilin (S3) antibody

Immunogen :

Synthesized peptide derived from human Cofilin around the phosphorylation site of S3.

Epitope :

10-90 aa

Localization :

Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Specificity :

Phospho-Cofilin (S3) Polyclonal Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, IHC-p, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage