Anti-Cleaved-Notch 1 (V1754) antibody | St John's Laboratory STJ90066 product information

product summary

company name :

St John's Laboratory

product type :

antibody

product name :

Anti-Cleaved-Notch 1 (V1754) antibody

catalog :

STJ90066

quantity :

100μl

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

more info or order :

St John's Laboratory product webpage

image

image 1 :

Western blot (WB) analysis of Cleaved-Notch 1 (V1754) Polyclonal Antibody.

product information

Catalog Number :

STJ90066

Product Name :

Anti-Cleaved-Notch 1 (V1754) antibody

Product Type :

Primary Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

Cleaved

Isotype :

IgG

Size :

100μl

List Price :

150 USD

Product Description :

Notch 1 is a protein encoded by the NOTCH1 gene which is approximately 272,5 kDa. Notch 1 is localised to the cell membrane. It is involved in the notch signalling pathway and Notch 2 activation and transmission of signal to the nucleus. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch 1 is expressed in most adult tissues but is found mainly in lymphoid tissues. Mutations in the NOTCH1 gene may result in aortic valve disease and Adams-Oliver syndrome. STJ90066 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.

CrossReactivity :

Human, Mouse, Rat

ALTnames :

NOTCH1 antibody, TAN1 antibody, Neurogenic locus notch homolog protein 1 antibody, Notch 1 antibody, hN1 antibody, Translocation-associated notch protein TAN-1 antibody, Notch 1 extracellular truncation antibody, NEXT antibody, Notch 1 intracellular domain antibody, NICD antibody, Cleaved-Notch 1 (V1754) antibody

Immunogen :

Synthesized peptide derived from human Notch 1

Epitope :

1710-1790 aa, Internal

Localization :

Cell membrane ; Notch 1 intracellular domain: Nucleus Note=Following proteolytical processing NICD is translocated to the nucleus.

Specificity :

Cleaved-Notch 1 (V1754) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.

Purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer :

Liquid in PBS containing 50% glycerol, 0.5% BSA

Preservative :

0.02% sodium azide

Concentration :

1 mg/ml

Application Summary :

WB, ELISA

Storage :

Store at -20°C, and avoid repeat freeze-thaw cycles.

more info or order :

St John's Laboratory product webpage