product summary
company name :
St John's Laboratory
product type :
antibody
product name :
Anti-AXIN2 antibody
catalog :
STJ26209
quantity :
100μl
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
application :
western blot, immunohistochemistry
more info or order :
product information
Catalog Number :
STJ26209
Product Name :
Anti-AXIN2 antibody
Product Type :
Primary Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Isotype :
IgG
Size :
100μl
List Price :
230 USD
Product Description :
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
CrossReactivity :
Human, Mouse
ALTnames :
AXIN2 antibody
Immunogen :
Recombinant peptide derived from human AXIN2.
Purity :
Anti-AXIN2 antibody was affinity purified using immunizing peptide
Buffer :
PBS, 50% glycerol, pH7.4
Preservative :
0.02% sodium azide
Concentration :
1 mg/ml
Application Summary :
WB,IHC
Storage :
Store at -20°C, and avoid repeat freeze-thaw cycles.
more info or order :
company information
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com+44 (0)2072322321
headquarters: UK