product summary
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company name :
Sino Biological
product type :
protein
product name :
Human XRCC5 & XRCC6 Heterodimer Protein
catalog :
CT018-H07B
quantity :
50 µg
price :
298 USD
more info or order :
Sino Biological product webpage
citations: 7
Reference
Wang Y, Shen F, Zhao C, Li J, Wang W, Li Y, et al. Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining. Nucleic Acids Res. 2025;53: pubmed publisher
Pan Q, Luo P, Shi C. PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair. J Biol Chem. 2023;:105032 pubmed publisher
Chuang T, Su C, Wu P, Chang Y, Tarn W. LncRNA HOTAIRM1 functions in DNA double-strand break repair via its association with DNA repair and mRNA surveillance factors. Nucleic Acids Res. 2023;51:3166-3184 pubmed publisher
Ning K, Wang Z, Cheng F, Yan Z, Qiu J. The small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication. PLoS Pathog. 2022;18:e1010578 pubmed publisher
Meza Sosa K, Miao R, Navarro F, Zhang Z, Zhang Y, Hu J, et al. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Mol Cell. 2022;82:785-802.e10 pubmed publisher
Singh J, Smith R, Rother M, de Groot A, Wiegant W, Vreeken K, et al. Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining. Nat Commun. 2021;12:6560 pubmed publisher
Weterings E, Gallegos A, Dominick L, Cooke L, Bartels T, Vagner J, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016;43:98-106 pubmed publisher
image
image 1 :
Sino Biological CT018-H07B image 1
product information
Catalog Number :
CT018-H07B
Product Name :
Human XRCC5 & XRCC6 Heterodimer Protein
Product Type :
Protein
Host Species :
Baculovirus-Insect Cells
Conjugation :
N-His
Size :
50 µg
List Price :
298 USD
Gene ID :
P13010 & P12956
Product Description :
A DNA sequence encoding the Human XRCC5 (P13010) (Met 1-Ile 732) was fused with a polyhistidine tag at the N-terminus, constructed the plasmid 1; A DNA sequence encoding the Human XRCC6 (P12956) (Met 1-Asp 609) was fused with a polyhistidine tag at the N-terminus, constructed the plasmid 2. The two plasmids were co-expressed and the heterodimer was purified.
SpeciesSummary :
Human
ALTnames :
XRCC5 & XRCC6
Purity :
> 90 % as determined by SDS-PAGE
Buffer :
Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.0
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
Sino Biological product webpage
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.