Mouse Legumain/ LGMN Protein (His Tag) | Sino Biological 50051-M07H product information

product summary

company name :

Sino Biological

product type :

protein

product name :

Mouse Legumain/ LGMN Protein (His Tag)

catalog :

50051-M07H

quantity :

50 µg

price :

298 USD

more info or order :

Sino Biological product webpage

citations: 11

Reference
Liu Y, Xie Y, Chen Y, Duan J, Bao C, Wang J, et al. A protease-cleavable liposome for co-delivery of anti-PD-L1 and doxorubicin for colon cancer therapy in mice. Nat Commun. 2025;16:2854 pubmed publisher
Yan M, Tang L, Dai L, Lei C, Xiong M, Zhang X, et al. Cofilin promotes tau pathology in Alzheimer's disease. Cell Rep. 2023;42:112138 pubmed publisher
Chen G, Ahn E, Kang S, Xia Y, Liu X, Zhang Z, et al. UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Adv Sci (Weinh). 2022;9:e2103396 pubmed publisher
Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, et al. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. elife. 2021;10: pubmed publisher
Chen G, Kang S, Wang Z, Ahn E, Xia Y, Liu X, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Sci Adv. 2021;7: pubmed publisher
Wang Z, Wu W, Kang S, Liu X, Wu Z, Peng J, et al. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. JCI Insight. 2018;3: pubmed publisher
Zhou H, Sun H, Lv S, Zhang D, Zhang X, Tang Z, et al. Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release. Acta Biomater. 2017;54:227-238 pubmed publisher
Hasegawa S, Inoue D, Yamasaki M, Li C, Imai M, Takahashi N, et al. Site-specific cleavage of acetoacetyl-CoA synthetase by legumain. FEBS Lett. 2016;590:1592-601 pubmed publisher
Hasegawa S, Yamasaki M, Fukui T. Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney. Biochem Biophys Res Commun. 2014;453:631-5 pubmed publisher
Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, et al. Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Nat Commun. 2014;5:4280 pubmed publisher
Zhao L, Hua T, CROWLEY C, Ru H, Ni X, Shaw N, et al. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014;24:344-58 pubmed publisher

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product information

Catalog Number :

50051-M07H

Product Name :

Mouse Legumain/ LGMN Protein (His Tag)

Product Type :

Protein

Host Species :

HEK293 Cells

Conjugation :

N-His

Size :

50 µg

List Price :

298 USD

Gene ID :

NP_035305.1

Product Description :

A DNA sequence encoding the extracellular domain (Val 18-Tyr 435) of mouse LGMN (NP_035305.1) precursor was expressed with a C-terminal polyhistidine tag.

SpeciesSummary :

Mouse

ALTnames :

AEP,Prsc1,Lgmn

Purity :

≥ 75 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Buffer :

Supplied as sterile 25mM Tris, 0.15M NaCl, 20% Glycerol, pH 7.5

Packaging :

Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.

Storage :

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

more info or order :

Sino Biological product webpage