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company name :
Sino Biological
product type :
protein
product name :
SARS-CoV-2 Spike RBD (L452R,T478K) Protein (His Tag)
catalog :
40592-V08H90
quantity :
100 µg
price :
448 USD
more info or order :
Sino Biological product webpage
citations: 15
Reference
Thompson A, Sankaranarayanan N, Chittum J, Mahida V, Vishweshwara S, Raigawali R, et al. Identification of an Unnatural Sulfated Monosaccharide as a High-Affinity Ligand for Pan-Variant Targeting of SARS-CoV-2 Spike Glycoprotein. ACS Chem Biol. 2025;20:1394-1405 pubmed publisher
Ana Sosa Batiz F, Verma S, Shafee N, Miller R, Conner C, Hastie K, et al. A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity. EBioMedicine. 2025;113:105619 pubmed publisher
Chen Y, Zha J, Xu S, Shao J, Liu X, Li D, et al. Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation. Viruses. 2024;16: pubmed publisher
Park S, Choi J, Lee Y, Noh J, Kim N, Lee J, et al. An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation. Nat Commun. 2024;15:3368 pubmed publisher
Zhang R, Liu X, Guo Y, Chen C. SARS-CoV-2 spike protein receptor binding domain promotes IL-6 and IL-8 release via ATP/P2Y2 and ERK1/2 signaling pathways in human bronchial epithelia. Mol Immunol. 2024;167:53-61 pubmed publisher
Yu X, Pan B, Zhao C, Shorty D, Solano L, Sun G, et al. Discovery of Peptidic Ligands against the SARS-CoV-2 Spike Protein and Their Use in the Development of a Highly Sensitive Personal Use Colorimetric COVID-19 Biosensor. ACS Sens. 2023;8:2159-2168 pubmed publisher
Wang M, Yan H, Chen L, Wang Y, Li L, Zhang H, et al. Oxalic acid blocked the binding of spike protein from SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) variants to human angiotensin-converting enzymes 2. PLoS ONE. 2023;18:e0285722 pubmed publisher
Emmenegger M, Worth R, Fiedler S, Devenish S, Knowles T, Aguzzi A. Protocol to determine antibody affinity and concentration in complex solutions using microfluidic antibody affinity profiling. STAR Protoc. 2023;4:102095 pubmed publisher
Wang Y, Yan A, Song D, Dong C, Rao M, Gao Y, et al. Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov. 2023;9:3 pubmed publisher
Kim J, Min S, Lee J, Shin H, Choi H, Yang H, et al. Development and Characterization of Phage-Display-Derived Novel Human Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2. Biomedicines. 2022;10: pubmed publisher
Zhang J, Huang Y, Sun M, Song T, Wan S, Yang C, et al. Mechanosensing view of SARS-CoV-2 infection by a DNA nano-assembly. Cell Rep Phys Sci. 2022;3:101048 pubmed publisher
Peng L, Fang Z, Renauer P, McNamara A, Park J, Lin Q, et al. Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species. Cell Rep. 2022;40:111160 pubmed publisher
Emmenegger M, Fiedler S, Brugger S, Devenish S, Morgunov A, Ilsley A, et al. Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants. iScience. 2022;25:104766 pubmed publisher
Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, et al. Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell. 2022;185:1389-1401.e18 pubmed publisher
Ren W, Ju X, Gong M, Lan J, Yu Y, Long Q, et al. Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. MBio. 2022;13:e0009922 pubmed publisher
image
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Sino Biological 40592-V08H90 image 1
product information
Catalog Number :
40592-V08H90
Product Name :
SARS-CoV-2 Spike RBD (L452R,T478K) Protein (His Tag)
Product Type :
Protein
Host Species :
HEK293 Cells
Conjugation :
C-His
Size :
100 µg
List Price :
448 USD
Gene ID :
YP_009724390.1
Product Description :
A DNA sequence encoding the SARS-CoV-2 Spike RBD (YP_009724390.1, with mutations L452R,T478K) (Arg319-Phe541) was expressed with a polyhistidine tag at the C-terminus. The mutations were identified in the SARS-CoV-2 variant (known as variant B.1.617.2) which emerged in the India.
SpeciesSummary :
SARS-CoV-2
ALTnames :
Spike
Purity :
> 95 % as determined by SDS-PAGE.
Buffer :
Lyophilized from sterile PBS, pH 7.4.
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
Sino Biological product webpage
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.