product summary
Loading...
company name :
Sino Biological
product type :
protein
product name :
SARS-CoV-2 (2019-nCoV) Spike RBD-Fc Recombinant Protein (HPLC-verified)
catalog :
40592-V02H
quantity :
100 µg
price :
448 USD
more info or order :
Sino Biological product webpage
citations: 22
Reference
Tang Y, Tang K, Hu Y, Ye Z, Luo W, Luo C, et al. M protein ectodomain-specific immunity restrains SARS-CoV-2 variants replication. Front Immunol. 2024;15:1450114 pubmed publisher
Chen F, Liu Z, Kang W, Jiang F, Yang X, Yin F, et al. Single-domain antibodies against SARS-CoV-2 RBD from a two-stage phage screening of universal and focused synthetic libraries. BMC Infect Dis. 2024;24:199 pubmed publisher
Teng F, Gang O, Freimuth P. Overexpression of human ACE2 protein in mouse fibroblasts stably transfected with the intact ACE2 gene. Virology. 2024;592:109988 pubmed publisher
Aksu M, Kumar P, G xfc ttler T, Taxer W, Gregor K, Mu xdf il B, et al. Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Res. 2024;221:105778 pubmed publisher
Hunt A, V xf6 geli B, Hassan A, Guerrero L, Kightlinger W, Yoesep D, et al. A rapid cell-free expression and screening platform for antibody discovery. Nat Commun. 2023;14:3897 pubmed publisher
Wang T, Lin X, Li Y, Lu Y. Artificial Lipid Biomembranes for Full-Length SARS-CoV-2 Receptor. Adv Mater. 2023;35:e2300575 pubmed publisher
He S, Wang J, Chen H, Qian Z, Hu K, Shi B, et al. A Competitive Panning Method Reveals an Anti-SARS-CoV-2 Nanobody Specific for an RBD-ACE2 Binding Site. Vaccines (Basel). 2023;11: pubmed publisher
Song J, Chow R, Pe xf1 a Hern xe1 ndez M, Zhang L, Loeb S, So E, et al. LRRC15 inhibits SARS-CoV-2 cellular entry in trans. PLoS Biol. 2022;20:e3001805 pubmed publisher
Shoemaker R, Panettieri R, Libutti S, Hochster H, Watts N, Wingfield P, et al. Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer. PLoS ONE. 2022;17:e0271066 pubmed publisher
Wei J, Shang R, Wang J, Zhu S, Yin J, Chen Y, et al. ACE2 overexpressing mesenchymal stem cells alleviates COVID-19 lung injury by inhibiting pyroptosis. iScience. 2022;25:104046 pubmed publisher
Song J, Chow R, Pena Hernandez M, Zhang L, Loeb S, So E, et al. LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans. bioRxiv. 2021;: pubmed publisher
Egorov A, Griffin S, Fuzawa M, Kobylanski J, Grindstaff R, Padgett W, et al. A Multiplex Noninvasive Salivary Antibody Assay for SARS-CoV-2 Infection and Its Application in a Population-Based Survey by Mail. Microbiol Spectr. 2021;9:e0069321 pubmed publisher
Guttler T, Aksu M, Dickmanns A, Stegmann K, Gregor K, Rees R, et al. Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO J. 2021;40:e107985 pubmed publisher
Ouyang W, Xie T, Fang H, Gao C, Stantchev T, Clouse K, et al. Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo. Int J Mol Sci. 2021;22: pubmed publisher
Wang X, Zhang M, He N, Wang Y, Yan C, Chen X, et al. Potent Neutralizing Antibodies Elicited by RBD-Fc-Based COVID-19 Vaccine Candidate Adjuvanted by the Th2-Skewing iNKT Cell Agonist. J Med Chem. 2021;64:11554-11569 pubmed publisher
Heggestad J, Kinnamon D, Olson L, Liu J, Kelly G, Wall S, et al. Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test. Sci Adv. 2021;7: pubmed publisher
Pedrosa M, Valenzuela R, Garrido Gil P, Labandeira C, Navarro G, Franco R, et al. Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clin Sci (Lond). 2021;135:465-481 pubmed publisher
Hanson Q, Wilson K, Shen M, Itkin Z, Eastman R, Shinn P, et al. Targeting ACE2-RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay. ACS Pharmacol Transl Sci. 2020;3:1352-1360 pubmed publisher
Samuel R, Majd H, Richter M, Ghazizadeh Z, Zekavat S, Navickas A, et al. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020;27:876-889.e12 pubmed publisher
Heggestad J, Kinnamon D, Olson L, Liu J, Kelly G, Wall S, et al. Multiplexed, quantitative serological profiling of COVID-19 from a drop of blood by a point-of-care test. medRxiv. 2020;: pubmed publisher
Hanson Q, Wilson K, Shen M, Itkin Z, Eastman R, Shinn P, et al. Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay. bioRxiv. 2020;: pubmed publisher
Ghazizadeh Z, Majd H, Richter M, Samuel R, Zekavat S, Asgharian H, et al. Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. bioRxiv. 2020;: pubmed publisher
image
image 1 :
Sino Biological 40592-V02H image 1
product information
Catalog Number :
40592-V02H
Product Name :
SARS-CoV-2 (2019-nCoV) Spike RBD-Fc Recombinant Protein (HPLC-verified)
Product Type :
Protein
Host Species :
HEK293 Cells
Conjugation :
C-human IgG1-Fc
Size :
100 µg
List Price :
448 USD
Gene ID :
YP_009724390.1
Product Description :
A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) Spike Protein (RBD) (YP_009724390.1) (Arg319-Phe541) was expressed with the Fc region of human IgG1 at the C-terminus.
SpeciesSummary :
SARS-CoV-2
ALTnames :
Spike
Purity :
> 95 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
Buffer :
Lyophilized from sterile PBS, pH 7.4.
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
Sino Biological product webpage
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.