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company name :
Sino Biological
product type :
protein
product name :
SARS-CoV-2 B.1.1.529 (Omicron) S1+S2 trimer Protein ( ECD, His Tag) (HPLC-verified)
catalog :
40589-V08H26
quantity :
100 µg
price :
518 USD
more info or order :
Sino Biological product webpage
citations: 18
Reference
Thompson A, Sankaranarayanan N, Chittum J, Mahida V, Vishweshwara S, Raigawali R, et al. Identification of an Unnatural Sulfated Monosaccharide as a High-Affinity Ligand for Pan-Variant Targeting of SARS-CoV-2 Spike Glycoprotein. ACS Chem Biol. 2025;20:1394-1405 pubmed publisher
Meany E, Klich J, Jons C, Mao T, Chaudhary N, Utz A, et al. Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines. Sci Adv. 2025;11:eadr2631 pubmed publisher
Bong Y, Brown D, Chung E, Ananthaswamy N, Chen R, Lewoczko E, et al. S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines. Front Immunol. 2024;15:1495561 pubmed publisher
Guenthoer J, Garrett M, Lilly M, Depierreux D, Ruiz F, Chi M, et al. The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2. PLoS Pathog. 2024;20:e1012383 pubmed publisher
Sibille G, Mannino G, Frasson I, Pavan M, Luganini A, Salata C, et al. The Novel A-Type Proanthocyanidin-Rich Phytocomplex SP4™ Acts as a Broad-Spectrum Antiviral Agent against Human Respiratory Viruses. Int J Mol Sci. 2024;25: pubmed publisher
Sui Y, Kar S, Chawla B, Hoang T, Yu Y, Wallace S, et al. Adjuvanted subunit intranasal vaccine prevents SARS-CoV-2 onward transmission in hamsters. bioRxiv. 2024;: pubmed publisher
Liu R, Natekar J, Kim K, Pathak H, Bhatnagar N, Raha J, et al. Multivalent and Sequential Heterologous Spike Protein Vaccinations Effectively Induce Protective Humoral Immunity against SARS-CoV-2 Variants. Vaccines (Basel). 2024;12: pubmed publisher
Saraf A, Gurjar R, Kaviraj S, Kulkarni A, Kumar D, Kulkarni R, et al. An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial. Nat Med. 2024;30:1363-1372 pubmed publisher
Chen J, Ho W, Yin B, Zhang Q, Li C, Yan J, et al. Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitive detection of SARS-CoV-2 spike protein. Biosens Bioelectron. 2024;248:115969 pubmed publisher
Heo C, Lim W, Yang J, Son S, Kim S, Kim D, et al. Novel S2 subunit-specific antibody with broad neutralizing activity against SARS-CoV-2 variants of concern. Front Immunol. 2023;14:1307693 pubmed publisher
Hornsby H, Nicols A, Longet S, Liu C, Tomic A, Angyal A, et al. Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history. Nat Commun. 2023;14:5065 pubmed publisher
Hernández N, Jankowski W, Frick R, Kelow S, Lubin J, Simhadri V, et al. Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel S. Heliyon. 2023;9:e15032 pubmed publisher
Wussow F, Kha M, Kim T, Ly M, Yll Pico M, Kar S, et al. Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants. NPJ Vaccines. 2023;8:41 pubmed publisher
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, et al. Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine. Cell Host Microbe. 2022;30:1732-1744.e7 pubmed publisher
Li H, Zhu B, Li B, Chen L, Ning X, Dong H, et al. Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensors. Sci Rep. 2022;12:15496 pubmed publisher
Xu Y, Wu C, Cao X, Gu C, Liu H, Jiang M, et al. Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res. 2022;32:609-620 pubmed publisher
Du P, Li N, Xiong X, Tang S, Dai Q, Liu Z, et al. A bivalent vaccine containing D614G and BA.1 spike trimer proteins or a BA.1 spike trimer protein booster shows broad neutralizing immunity. J Med Virol. 2022;: pubmed publisher
Wang S, Sun H, Zhang Y, Yuan L, Wang Y, Zhang T, et al. Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron. Cell Rep. 2022;39:110862 pubmed publisher
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Sino Biological 40589-V08H26 image 1
product information
Catalog Number :
40589-V08H26
Product Name :
SARS-CoV-2 B.1.1.529 (Omicron) S1+S2 trimer Protein ( ECD, His Tag) (HPLC-verified)
Product Type :
Protein
Host Species :
HEK293 Cells
Conjugation :
C-His
Size :
100 µg
List Price :
518 USD
Gene ID :
YP_009724390.1
Product Description :
A DNA sequence encoding the SARS-CoV-2 Spike S1+S2 (YP_009724390.1, with mutations A67V, HV69-70 deletion, T95I, G142D, VYY143-145 deletion, N211 deletion, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, F817P, N856K, A892P, A899P, A942P, Q954H, N969K, L981F, K986P, V987P and furin cleavage site mutants) expressed with the bacteriophage T4 fibritin and a polyhistidine tag at the C-terminus. The mutations were identified in the SARS-CoV-2 variant (known as variant B.1.1.529) which emerged in the South Africa.
SpeciesSummary :
SARS-CoV-2
ALTnames :
Spike
Purity :
> 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
Buffer :
Lyophilized from a sodium citrate buffer system at pH 6.0.
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
Sino Biological product webpage
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.