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company name :
Sino Biological
product type :
protein
product name :
SARS-CoV-2 (2019-nCoV) Nucleocapsid-His recombinant Protein
catalog :
40588-V08B
quantity :
100 µg
price :
448 USD
more info or order :
citations: 64
Published Application/Species/Sample/DilutionReference
  • neutralization; SARS coronavirus
Wang Z, Yang X, Zhou Y, Sun J, Liu X, Zhang J, et al. COVID-19 Severity Correlates with Weaker T-Cell Immunity, Hypercytokinemia, and Lung Epithelium Injury. Am J Respir Crit Care Med. 2020;202:606-610 pubmed publisher
Sadler C, Sandler J, Shamsabadi A, Frenette L, Creamer A, Stevens M. Signal Enhancement in Immunoassays via Coupling to Catalytic Nanoparticles. ACS Sens. 2025;10:4622-4633 pubmed publisher
Bean D, Liang Y, Avila F, He X, Asundi A, Sagar M. Endemic coronavirus infection is associated with SARS-CoV-2 Fc receptor-binding antibodies. J Virol. 2025;99:e0055025 pubmed publisher
Neville A, Conrin M, Schulze T, Davis P. A selective C5a-derived peptidomimetic enhances IgG response following inactivated SARS-CoV-2 immunization and confers rapid disease resolution following murine coronavirus infection. Front Immunol. 2025;16:1470034 pubmed publisher
Hofstee M, Kaczorowska J, Postema A, Zomer E, van Waalwijk M, Jonathans G, et al. High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents. Immun Ageing. 2025;22:1 pubmed publisher
Esen M, Fischer Herr J, Gabor J, Gaile J, Fleischmann W, Smeenk G, et al. First-in-Human Phase I Trial to Assess the Safety and Immunogenicity of an Orf Virus-Based COVID-19 Vaccine Booster. Vaccines (Basel). 2024;12: pubmed publisher
Zhang L, Wen S, Khan J, Liu Y, Maddahfar M, Zhou J, et al. Ultrasensitive Rapid Antigen Test by Geometric Lateral Flow Assays and Highly Doped Upconversion Nanoparticles. Anal Chem. 2024;96:16581-16589 pubmed publisher
Wang C, Shen W, Li Z, Xia X, Li J, Xu C, et al. 3D Film-Like Nanozyme with a Synergistic Amplification Effect for the Ultrasensitive Immunochromatographic Detection of Respiratory Viruses. ACS Nano. 2024;18:25865-25879 pubmed publisher
Jung W, Abdelnour A, Kaplonek P, Herrero R, Shih Lu Lee J, Barbati D, et al. SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner. Cell Rep. 2024;43:114684 pubmed publisher
Geanes E, McLennan R, Pierce S, Menden H, Paul O, Sampath V, et al. SARS-CoV-2 envelope protein regulates innate immune tolerance. iScience. 2024;27:109975 pubmed publisher
Dalapati T, Williams C, Giorgi E, Hurst J, Herbek S, Chen J, et al. Immunogenicity of Monovalent mRNA-1273 and BNT162b2 Vaccines in Children <5 Years of Age. Pediatrics. 2024;153: pubmed publisher
Ivanova E, Shwetar J, Devlin J, Buus T, Gray Gaillard S, Koide A, et al. mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection. iScience. 2023;26:108572 pubmed publisher
Heo C, Lim W, Yang J, Son S, Kim S, Kim D, et al. Novel S2 subunit-specific antibody with broad neutralizing activity against SARS-CoV-2 variants of concern. Front Immunol. 2023;14:1307693 pubmed publisher
Taks E, Moorlag S, F xf6 hse K, Simonetti E, van der Gaast de Jongh C, van Werkhoven C, et al. The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination. iScience. 2023;26:108062 pubmed publisher
Chiuppesi F, Ortega Francisco S, Gutiérrez M, Li J, Ly M, Faircloth K, et al. Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplantation and Cellular Therapy. Vaccines (Basel). 2023;11: pubmed publisher
Lin C, Liu Z, Fang F, Zhao S, Li Y, Xu M, et al. Next-Generation Rapid and Ultrasensitive Lateral Flow Immunoassay for Detection of SARS-CoV-2 Variants. ACS Sens. 2023;8:3733-3743 pubmed publisher
Schaefer Babajew D, Wang Z, Muecksch F, Cho A, Loewe M, Cipolla M, et al. Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination. Nature. 2023;613:735-742 pubmed publisher
Samanovic M, Oom A, Cornelius A, Gray Gaillard S, Karmacharya T, Tuen M, et al. Vaccine-Acquired SARS-CoV-2 Immunity versus Infection-Acquired Immunity: A Comparison of Three COVID-19 Vaccines. Vaccines (Basel). 2022;10: pubmed publisher
Hajnik R, Plante J, Liang Y, Alameh M, Tang J, Bonam S, et al. Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models. Sci Transl Med. 2022;14:eabq1945 pubmed publisher
L xf3 pez Mu xf1 oz A, Kosik I, Hollý J, Yewdell J. Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity. Sci Adv. 2022;8:eabp9770 pubmed publisher
Chiuppesi F, Zaia J, Faircloth K, Johnson D, Ly M, Karpinski V, et al. Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants. iScience. 2022;25:104745 pubmed publisher
Wussow F, Kha M, Faircloth K, Nguyen V, Iniguez A, Martinez J, et al. COH04S1 and beta sequence-modified vaccine protect hamsters from SARS-CoV-2 variants. iScience. 2022;25:104457 pubmed publisher
Li W, Kitsios G, Bain W, Wang C, Li T, Fanning K, et al. Stability of SARS-CoV-2-Encoded Proteins and Their Antibody Levels Correlate with Interleukin 6 in COVID-19 Patients. mSystems. 2022;7:e0005822 pubmed publisher
Nakayama E, Kubota Koketsu R, Sasaki T, Suzuki K, Uno K, Shimizu J, et al. Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein. Sci Rep. 2022;12:8108 pubmed publisher
Quach H, Ovsyannikova I, Poland G, Kennedy R. Detection of SARS-CoV-2 peptide-specific antibodies in Syrian hamster serum by ELISA. J Immunol Methods. 2022;505:113275 pubmed publisher
Lee J, Jung Y, Lee S, Kim J, Lee C, Kim S, et al. Rapid Biosensor of SARS-CoV-2 Using Specific Monoclonal Antibodies Recognizing Conserved Nucleocapsid Protein Epitopes. Viruses. 2022;14: pubmed publisher
Li M, Liu J, Lu R, Zhang Y, Du M, Xing M, et al. Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals. J Allergy Clin Immunol. 2022;149:1225-1241 pubmed publisher
Chiuppesi F, Nguyen V, Park Y, Contreras H, Karpinski V, Faircloth K, et al. Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates. NPJ Vaccines. 2022;7:7 pubmed publisher
D xed ez J, Romero C, Cruz M, Vandeberg P, Merritt W, Pradenas E, et al. Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Hyperimmune Immunoglobulin Demonstrates Potent Neutralization and Antibody-Dependent Cellular Cytotoxicity and Phagocytosis Through N and S Proteins. J Infect Dis. 2022;225:938-946 pubmed publisher
Agarwal D, Nandwana V, Henrich S, Josyula V, Thaxton C, Qi C, et al. Highly sensitive and ultra-rapid antigen-based detection of SARS-CoV-2 using nanomechanical sensor platform. Biosens Bioelectron. 2022;195:113647 pubmed publisher
Emeribe A, Abdullahi I, Shuwa H, Uzairue L, Musa S, Anka A, et al. Humoral immunological kinetics of severe acute respiratory syndrome coronavirus 2 infection and diagnostic performance of serological assays for coronavirus disease 2019: an analysis of global reports. Int Health. 2022;14:18-52 pubmed publisher
López Muñoz A, Kosik I, Hollý J, Yewdell J. Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive Immunity. bioRxiv. 2021;: pubmed publisher
Zhong C, Xia H, Adam A, Wang B, Hajnik R, Liang Y, et al. Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies. NPJ Vaccines. 2021;6:139 pubmed publisher
Verma A, Hawes C, Lakshmanappa Y, Roh J, Schmidt B, Dutra J, et al. Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation. Cell Rep. 2021;37:109942 pubmed publisher
Warner B, Santry L, Leacy A, Chan M, Pham P, Vendramelli R, et al. Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease. iScience. 2021;24:103219 pubmed publisher
Langellotto F, Dellacherie M, Yeager C, Ijaz H, Yu J, Cheng C, et al. A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens. Adv Healthc Mater. 2021;10:e2101370 pubmed publisher
Maghsood F, Hassani D, Salimi V, Kardar G, Khoshnoodi J, Ghaderi A, et al. Differential Antibody Response to SARS-CoV-2 Antigens in Recovered and Deceased Iranian COVID-19 Patients. Viral Immunol. 2021;34:708-713 pubmed publisher
Rice A, Verma M, Shin A, Zakin L, SIELING P, Tanaka S, et al. Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice. Sci Rep. 2021;11:14917 pubmed publisher
Super M, Doherty E, Cartwright M, Seiler B, Langellotto F, Dimitrakakis N, et al. Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock. Nat Biomed Eng. 2021;: pubmed publisher
Garrido C, Hurst J, Lorang C, Aquino J, Rodriguez J, Pfeiffer T, et al. Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents. JCI Insight. 2021;6: pubmed publisher
Wang Z, Muecksch F, Schaefer Babajew D, Finkin S, Viant C, Gaebler C, et al. Naturally enhanced neutralizing breadth to SARS-CoV-2 after one year. bioRxiv. 2021;: pubmed publisher
Low J, Vaqueirinho D, Mele F, Foglierini M, Jerak J, Perotti M, et al. Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2. Science. 2021;372:1336-1341 pubmed publisher
Mantus G, Nyhoff L, Kauffman R, Edara V, Lai L, Floyd K, et al. Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain. J Immunol. 2021;206:2605-2613 pubmed publisher
Yuen R, Steiner D, Pihl R, Chavez E, Olson A, Smith E, et al. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021;12:614676 pubmed publisher
Zhao M, Yu Y, Sun L, Xing J, Li T, Zhu Y, et al. GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein. Nat Commun. 2021;12:2114 pubmed publisher
Piepenbrink M, Park J, Oladunni F, Deshpande A, Basu M, Sarkar S, et al. Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters. Cell Rep Med. 2021;2:100218 pubmed publisher
Lu S, Xie X, Zhao L, Wang B, Zhu J, Yang T, et al. The immunodominant and neutralization linear epitopes for SARS-CoV-2. Cell Rep. 2021;34:108666 pubmed publisher
Drouot L, Hantz S, Jouen F, Velay A, Lamia B, Veber B, et al. Evaluation of Humoral Immunity to SARS-CoV-2: Diagnostic Value of a New Multiplex Addressable Laser Bead Immunoassay. Front Microbiol. 2020;11:603931 pubmed publisher
Kim H, Lee J, Kim M, Park S, Choi M, Lee W, et al. Development of a SARS-CoV-2-specific biosensor for antigen detection using scFv-Fc fusion proteins. Biosens Bioelectron. 2021;175:112868 pubmed publisher
Anderson E, Goodwin E, Verma A, Arevalo C, Bolton M, Weirick M, et al. Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection. medRxiv. 2020;: pubmed publisher
Torrente Rodríguez R, Lukas H, Tu J, Min J, Yang Y, Xu C, et al. SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring. Matter. 2020;3:1981-1998 pubmed publisher
Chang A, Croix M, Kenney P, Baron S, Hicar M. Serum Responses of Children With Kawasaki Disease Against Severe Acute Respiratory Syndrome Coronavirus 2 Proteins. Pediatr Infect Dis J. 2020;39:e366-e367 pubmed publisher
Sohn K, Lee S, Kim H, Cheon S, Jeong H, Lee J, et al. COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis. J Korean Med Sci. 2020;35:e343 pubmed publisher
Cazares L, Chaerkady R, Samuel Weng S, Boo C, Cimbro R, Hsu H, et al. Development of a Parallel Reaction Monitoring Mass Spectrometry Assay for the Detection of SARS-CoV-2 Spike Glycoprotein and Nucleoprotein. Anal Chem. 2020;92:13813-13821 pubmed publisher
van Tol S, Mögling R, Li W, Godeke G, Swart A, Bergmans B, et al. Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach. Emerg Microbes Infect. 2020;9:1965-1973 pubmed publisher
Elizaldi S, Lakshmanappa Y, Roh J, Schmidt B, Carroll T, Weaver K, et al. SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques. Res Sq. 2020;: pubmed publisher
McAndrews K, Dowlatshahi D, Dai J, Becker L, Hensel J, Snowden L, et al. Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity. JCI Insight. 2020;5: pubmed publisher
den Hartog G, Schepp R, Kuijer M, Geurtsvankessel C, van Beek J, Rots N, et al. SARS-CoV-2-Specific Antibody Detection for Seroepidemiology: A Multiplex Analysis Approach Accounting for Accurate Seroprevalence. J Infect Dis. 2020;222:1452-1461 pubmed publisher
Elizaldi S, Lakshmanappa Y, Roh J, Schmidt B, Carroll T, Weaver K, et al. SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques. bioRxiv. 2020;: pubmed publisher
Chiuppesi F, Salazar M, Contreras H, Nguyen V, Martinez J, Park S, et al. Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine. bioRxiv. 2020;: pubmed publisher
Yee J, Van Rompay K, Carpenter A, Nham P, Halley B, Iyer S, et al. SARS-CoV-2 surveillance for a non-human primate breeding research facility. J Med Primatol. 2020;: pubmed publisher
Lei H, Ye F, Liu X, Huang Z, Ling S, Jiang Z, et al. SARS-CoV-2 environmental contamination associated with persistently infected COVID-19 patients. Influenza Other Respir Viruses. 2020;: pubmed publisher
Sun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, et al. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerg Microbes Infect. 2020;9:940-948 pubmed publisher
Takasugi M, Hildemann W. Regulation of immunity toward allogeneic tumors in mice. I. Effect of antiserum fractions on tumor growth. J Natl Cancer Inst. 1969;43:843-56 pubmed
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Sino Biological 40588-V08B image 1
product information
Catalog Number :
40588-V08B
Product Name :
SARS-CoV-2 (2019-nCoV) Nucleocapsid-His recombinant Protein
Product Type :
Protein
Host Species :
Baculovirus-Insect Cells
Conjugation :
C-His
Size :
100 µg
List Price :
448 USD
Gene ID :
YP_009724397.2
Product Description :
A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) Nucleocapsid Protein (YP_009724397.2(335Gly/Ala)) (Met1-Ala419) was expressed with a polyhistidine tag at the C-terminus.
SpeciesSummary :
SARS-CoV-2
ALTnames :
NP-CoV
Purity :
> 90 % as determined by SDS-PAGE.
Buffer :
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH8.0, 10%glycerol
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.