product summary
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company name :
Sino Biological
product type :
protein
product name :
Human ERN1 / IRE1 Protein (aa 465-977, His & GST Tag)
catalog :
11905-H20B
quantity :
50 µg
price :
258 USD
more info or order :
Sino Biological product webpage
citations: 6
Reference
Jiang D, Guo Y, Wang T, Wang L, Yan Y, Xia L, et al. IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis. Nat Commun. 2024;15:4114 pubmed publisher
Jiang K, Liu C, Nie L, Jiang H, Xu L, Zhang K, et al. Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition. Acta Pharmacol Sin. 2023;44:234-243 pubmed publisher
Pelizzari Raymundo D, Eriksson L, Chevet E, Guillory X. Structure-Based Drug Discovery of IRE1 Modulators. Methods Mol Biol. 2022;2378:293-315 pubmed publisher
Doultsinos D, Carlesso A, Chintha C, Paton J, Paton A, Samali A, et al. Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1 activity. FEBS J. 2020;: pubmed publisher
Zhu X, Zhang J, Sun H, Jiang C, Dong Y, Shan Q, et al. Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. J Biol Chem. 2014;289:30567-77 pubmed publisher
Lu Y, Liang F, Wang X. A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol Cell. 2014;55:758-70 pubmed publisher
image
image 1 :
Sino Biological 11905-H20B image 1
product information
Catalog Number :
11905-H20B
Product Name :
Human ERN1 / IRE1 Protein (aa 465-977, His & GST Tag)
Product Type :
Protein
Host Species :
Baculovirus-Insect Cells
Conjugation :
N-GST & His
Size :
50 µg
List Price :
258 USD
Gene ID :
O75460-1
Product Description :
A DNA sequence encoding the human ERN1 isoform 1 (O75460-1) cytoplasmic domain (Pro 465-Leu 977) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
SpeciesSummary :
Human
ALTnames :
hIRE1p,IRE1,IRE1a,IRE1P,ERN1
Purity :
≥ 80 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Buffer :
Supplied as sterile 20mM Tris, 500M NaCl, 25% glycerol, 0.1mM EDTA, 0.5mM TCEP, 2mM GSH, pH 7.5.
Packaging :
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
Sino Biological product webpage
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.