| Published Application/Species/Sample/Dilution | Reference |
|---|
| Schlepckow K, Monroe K, Kleinberger G, Cantuti Castelvetri L, Parhizkar S, Xia D, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020;12:e11227 pubmed publisher |
| Rauchmann B, Sadlon A, Perneczky R. Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid. J Alzheimers Dis. 2020;73:1615-1626 pubmed publisher |
| Rauchmann B, Schneider Axmann T, Alexopoulos P, Perneczky R. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum. Neurobiol Aging. 2019;74:182-190 pubmed publisher |
| Woollacott I, Nicholas J, Heslegrave A, Heller C, Foiani M, Dick K, et al. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup. Alzheimers Res Ther. 2018;10:79 pubmed publisher |
| Jia Y, Ying X, Zhou J, Chen Y, Luo X, Xie S, et al. The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth. Cell Death Dis. 2018;9:603 pubmed publisher |
| Li Q, Zhang Y, Luo H, Wu Y, Qin J, Wang L, et al. Soluble TREM2 engages cell-surface nucleolin to drive vascular permeability and malignant ascites in ovarian cancer. EMBO Mol Med. 2026;18:2667-2690 pubmed publisher |
| Fuchs N, El Gaamouch F, Nada H, Cho S, Gabr M. High-throughput fragment screening identifies a new small molecule scaffold that modulates TREM2 Signaling. Bioorg Med Chem. 2026;137:118612 pubmed publisher |
| Nada H, Yuan S, El Gaamouch F, Cho S, Kuncewicz K, Calvo Barreiro L, et al. TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization. Eur J Med Chem. 2026;302:118358 pubmed publisher |
| Nada H, Calvo Barreiro L, Fuchs N, Kaur B, Cho S, Upadhyay S, et al. HTS-Oracle: Experimentally validated AI-enabled prioritization for generalizable small molecule hit discovery. bioRxiv. 2025;: pubmed publisher |
| Fuchs N, El Gaamouch F, Nada H, Cho S, Gabr M. High-Throughput Fragment Screening Identifies a New Small Molecule Scaffold that Modulates TREM2 Signaling. bioRxiv. 2025;: pubmed publisher |
| von Locquenghien M, Zwicky P, Xie K, Jaitin D, Sheban F, Yalin A, et al. Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy. Cell. 2025;188:7099-7117.e26 pubmed publisher |
| Fuchs N, Kuncewicz K, Gaamouch F, Gabr M. TREM2 hit discovery using temperature-related intensity change (TRIC) technology: A proof-of-concept high-throughput screening approach. SLAS Discov. 2025;35:100255 pubmed publisher |
| Fuchs N, Kuncewicz K, El Gaamouch F, Gabr M. TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach. bioRxiv. 2025;: pubmed publisher |
| Dahl xe9 n A, Roshanbin S, Aguilar X, Bucher N, Lopes van den Broek S, Sehlin D, et al. PET imaging of TREM2 in amyloid-beta induced neuroinflammation. Eur J Nucl Med Mol Imaging. 2025;: pubmed publisher |
| Kraller M, Fa xdf bender J, Jabali A, Kroeger J, Fink B, Popper B, et al. Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model. Alzheimers Res Ther. 2025;17:114 pubmed publisher |
| Reichert Plaska C, Heslegrave A, Bruno D, Ramos Cejudo J, Han Lee S, Osorio R, et al. Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression. Brain Behav Immun. 2024;120:248-255 pubmed publisher |
| Arsenault R, Marshall S, Salois P, Li Q, Zhang W. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway. Biology (Basel). 2024;13: pubmed publisher |
| Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, et al. Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. MAbs. 2022;14:2107971 pubmed publisher |
| Xie M, Liu Y, Zhao S, Zhang L, Bosco D, Pang Y, et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nat Neurosci. 2022;25:26-38 pubmed publisher |
| Szykowska A, Chen Y, Smith T, Preger C, Yang J, Qian D, et al. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure. 2021;: pubmed publisher |
| Banerjee G, Ambler G, Keshavan A, Paterson R, Foiani M, Toombs J, et al. Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy. J Alzheimers Dis. 2020;74:1189-1201 pubmed publisher |
| Wilson E, Swarovski M, Linortner P, Shahid M, Zuckerman A, Wang Q, et al. Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau. Brain. 2020;143:932-943 pubmed publisher |
| Ashton N, Suarez Calvet M, Heslegrave A, Hye A, Razquin C, Pastor P, et al. Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers. Alzheimers Res Ther. 2019;11:94 pubmed publisher |
| Jensen C, Bahl J, Østergaard L, Høgh P, Wermuth L, Heslegrave A, et al. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma. Exp Gerontol. 2019;121:91-98 pubmed publisher |
| Alosco M, Tripodis Y, Fritts N, Heslegrave A, Baugh C, Conneely S, et al. Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018;14:1159-1170 pubmed publisher |
| Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher |
| Nakanishi K, Morikane S, Ichikawa S, Kurohane K, Niwa Y, Akimoto Y, et al. Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA. Sci Rep. 2017;7:45843 pubmed publisher |
| Jendresen C, Arskog V, Daws M, Nilsson L. The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. J Neuroinflammation. 2017;14:59 pubmed publisher |
