Human TREM2 Protein (ECD,His Tag) | Sino Biological 11084-H08H product information

product summary

company name :

Sino Biological

product type :

protein

product name :

Human TREM2 Protein (ECD,His Tag)

catalog :

11084-H08H

quantity :

1 mg

price :

2188 USD

more info or order :

Sino Biological product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
western blot; human	Schlepckow K, Monroe K, Kleinberger G, Cantuti Castelvetri L, Parhizkar S, Xia D, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020;12:e11227 pubmed publisher
ELISA; human	Rauchmann B, Sadlon A, Perneczky R. Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid. J Alzheimers Dis. 2020;73:1615-1626 pubmed publisher
ELISA; human	Rauchmann B, Schneider Axmann T, Alexopoulos P, Perneczky R. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum. Neurobiol Aging. 2019;74:182-190 pubmed publisher
ELISA; human	Woollacott I, Nicholas J, Heslegrave A, Heller C, Foiani M, Dick K, et al. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup. Alzheimers Res Ther. 2018;10:79 pubmed publisher
ELISA; human	Jia Y, Ying X, Zhou J, Chen Y, Luo X, Xie S, et al. The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth. Cell Death Dis. 2018;9:603 pubmed publisher
	Dahl xe9 n A, Roshanbin S, Aguilar X, Bucher N, Lopes van den Broek S, Sehlin D, et al. PET imaging of TREM2 in amyloid-beta induced neuroinflammation. Eur J Nucl Med Mol Imaging. 2025;: pubmed publisher
	Kraller M, Fa xdf bender J, Jabali A, Kroeger J, Fink B, Popper B, et al. Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model. Alzheimers Res Ther. 2025;17:114 pubmed publisher
	Reichert Plaska C, Heslegrave A, Bruno D, Ramos Cejudo J, Han Lee S, Osorio R, et al. Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression. Brain Behav Immun. 2024;120:248-255 pubmed publisher
	Arsenault R, Marshall S, Salois P, Li Q, Zhang W. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway. Biology (Basel). 2024;13: pubmed publisher
	Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, et al. Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. MAbs. 2022;14:2107971 pubmed publisher
	Xie M, Liu Y, Zhao S, Zhang L, Bosco D, Pang Y, et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nat Neurosci. 2022;25:26-38 pubmed publisher
	Szykowska A, Chen Y, Smith T, Preger C, Yang J, Qian D, et al. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure. 2021;: pubmed publisher
	Banerjee G, Ambler G, Keshavan A, Paterson R, Foiani M, Toombs J, et al. Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy. J Alzheimers Dis. 2020;74:1189-1201 pubmed publisher
	Wilson E, Swarovski M, Linortner P, Shahid M, Zuckerman A, Wang Q, et al. Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau. Brain. 2020;143:932-943 pubmed publisher
	Ashton N, Suarez Calvet M, Heslegrave A, Hye A, Razquin C, Pastor P, et al. Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers. Alzheimers Res Ther. 2019;11:94 pubmed publisher
	Jensen C, Bahl J, Østergaard L, Høgh P, Wermuth L, Heslegrave A, et al. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma. Exp Gerontol. 2019;121:91-98 pubmed publisher
	Alosco M, Tripodis Y, Fritts N, Heslegrave A, Baugh C, Conneely S, et al. Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018;14:1159-1170 pubmed publisher
	Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
	Nakanishi K, Morikane S, Ichikawa S, Kurohane K, Niwa Y, Akimoto Y, et al. Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA. Sci Rep. 2017;7:45843 pubmed publisher
	Jendresen C, Arskog V, Daws M, Nilsson L. The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. J Neuroinflammation. 2017;14:59 pubmed publisher

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product information

Catalog Number :

11084-H08H

Product Name :

Human TREM2 Protein (ECD,His Tag)

Product Type :

Protein

Host Species :

HEK293 Cells

Conjugation :

C-His

Size :

1 mg

List Price :

2188 USD

Gene ID :

NP_061838.1

Product Description :

A DNA sequence encoding the extracellular domain of human TREM2 (NP_061838.1) (Met1-Ser174) was expressed fused with a polyhistidine tag at the C-terminus.

SpeciesSummary :

Human

ALTnames :

PLOSL2,TREM-2,Trem2a,Trem2b,Trem2c

Purity :

≥ 90 % as determined by SDS-PAGE.

Buffer :

Lyophilized from sterile PBS, pH 7.4.

Packaging :

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Storage :

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

more info or order :

Sino Biological product webpage