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company name :
Sino Biological
product type :
protein
product name :
Human TNF-alpha / TNFA Protein
catalog :
10602-HNAE
quantity :
1 mg
price :
1288 USD
more info or order :
citations: 43
Published Application/Species/Sample/DilutionReference
  • ELISA; human
Du J, Rehm B. Purification of target proteins from intracellular inclusions mediated by intein cleavable polyhydroxyalkanoate synthase fusions. Microb Cell Fact. 2017;16:184 pubmed publisher
  • FACS; human
Shen Y, Li G, Gu C, Chen B, Chen A, Li H, et al. T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα. PLoS ONE. 2017;12:e0177891 pubmed publisher
Yu T, Zou S, Long Y, Ou Y, Liu S, Kang T, et al. Glass fiber-interfaced CRISPR/Cas biosensing adaptable for diverse biomarker detection. Trends Biotechnol. 2025;43:2003-2028 pubmed publisher
Ren K, Niu B, Liang H, Xi C, Song M, Chen J, et al. Zhichuanling injection improves bronchial asthma by attenuation airway inflammation and epithelia-mesenchymal transition. J Ethnopharmacol. 2025;344:119540 pubmed publisher
Zhang L, Zhao P, Liu Y, Shi N, Zhou Y, Peng S, et al. Detection of TNF-α using the established ab-MPs-CLIA. Talanta. 2025;285:127301 pubmed publisher
Ma X, Zhang S, Ren X, Feng Y, Li H, Chen S, et al. Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency. Front Immunol. 2024;15:1434127 pubmed publisher
Sun Y, Wang J, Hu P, Tang Y, Wang Y, Ye J, et al. Molecular mechanism through which Tripterygium hypoglaucum (Lévl.) Hutch alleviates psoriasis. Biomed Pharmacother. 2024;181:117647 pubmed publisher
Awad A, Seetharaman A, Hossain M, Elshaer S, Abdelaziz R, Nader M, et al. Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy. Invest Ophthalmol Vis Sci. 2024;65:15 pubmed publisher
Hollis W, Farooq S, Khoshi M, Patel M, Karnaukhova E, Eller N, et al. Submicron immunoglobulin particles exhibit FcγRII-dependent toxicity linked to autophagy in TNFα-stimulated endothelial cells. Cell Mol Life Sci. 2024;81:376 pubmed publisher
Di Ianni A, Di Ianni A, Cowan K, Barbero L, Sirtori F. Leveraging Cross-Linking Mass Spectrometry for Modeling Antibody-Antigen Complexes. J Proteome Res. 2024;23:1049-1061 pubmed publisher
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, et al. TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression. J Cell Biol. 2024;223: pubmed publisher
Yeh Y, Kelly V, Pour R, Sirk S. A molecular toolkit for heterologous protein secretion across Bacteroides species. bioRxiv. 2023;: pubmed publisher
Ryu J, Jang C. A liquid crystal-based biosensor for sensitive detection of tumor necrosis factor-alpha. Mikrochim Acta. 2023;191:55 pubmed publisher
Miao Z, Ran J, Mou D, Wu S, Chen Y, Li C, et al. [YKL-40 Promotes the Expression of Inflammatory Factors in Type Ⅱ Alveolar Epithelial Cell Model of A549 Cell Line]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2023;54:954-958 pubmed publisher
Ran X, Zhu J, Ni R, Zheng Y, Chen Y, Zheng W, et al. TRIM5α recruits HDAC1 to p50 and Sp1 and promotes H3K9 deacetylation at the HIV-1 LTR. Nat Commun. 2023;14:3343 pubmed publisher
Dav xe9 E, Durrant O, Dhami N, Compson J, Broadbridge J, Archer S, et al. TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life. MAbs. 2023;15:2160229 pubmed publisher
Grasmeier M, Weber S, Treiber M, Thaler M, Luppa P. Surface plasmon resonance assays for the therapeutic drug monitoring of infliximab indicate clinical relevance of anti-infliximab antibody binding properties. Clin Chem Lab Med. 2023;61:1255-1265 pubmed publisher
Tang Y, Yang L, Liu H, Song Y, Yang Q, Liu Y, et al. Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis. Cell Rep. 2023;42:111948 pubmed publisher
Wang Z, Zou F, Wang A, Yang J, Jin R, Wang B, et al. Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1. Acta Pharmacol Sin. 2022;: pubmed publisher
Luo Z, Zhang R, Hu T, Zhu Y, Wu Y, Li W, et al. NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution. Genome Res. 2022;32:534-544 pubmed publisher
Valionyte E, Yang Y, Griffiths S, Bone A, Barrow E, Sharma V, et al. The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner. Cell Death Differ. 2021;: pubmed publisher
Zeng C, Waheed A, Li T, Yu J, Zheng Y, Yount J, et al. SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways. Sci Signal. 2021;14:eabc7611 pubmed publisher
Zhang J, Zhou B, Sun R, Ai Y, Cheng K, Li F, et al. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Res. 2021;: pubmed publisher
Gan D, Cheng W, Ke L, Sun A, Jia Q, Chen J, et al. Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis. Front Pharmacol. 2021;12:631891 pubmed publisher
Qi G, Yu K, Feng Y, Zhang Y, Shao Q, Yu M, et al. 1α,25-dihydroxyvitamin D3 promotes early osteogenic differentiation of PDLSCs and a 12-year follow-up case of early-onset vitamin D deficiency periodontitis. J Steroid Biochem Mol Biol. 2021;208:105805 pubmed publisher
Hou P, Luo L, Chen H, Chen Q, Bian X, Wu S, et al. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. Mol Cell. 2020;78:1192-1206.e10 pubmed publisher
Wu Y, Li C, Xia S, Tian X, Kong Y, Wang Z, et al. Identification of Human Single-Domain Antibodies against SARS-CoV-2. Cell Host Microbe. 2020;27:891-898.e5 pubmed publisher
Christler A, Felföldi E, Mosor M, Sauer D, Walch N, Dürauer A, et al. Semi-automation of process analytics reduces operator effect. Bioprocess Biosyst Eng. 2020;43:753-764 pubmed publisher
Hu Y, Liu J, Li X, Cai Y, He C, Li N, et al. Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin β-1/NF-κB signaling pathway. Cancer Lett. 2019;450:144-154 pubmed publisher
Zhou B, Zhang J, Liu X, Chen H, Ai Y, Cheng K, et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28:1171-1185 pubmed publisher
Sun J, Cui H, Gao Y, Pan Y, Zhou K, Huang J, et al. TGF-α Overexpression in Breast Cancer Bone Metastasis and Primary Lesions and TGF-α Enhancement of Expression of Procancer Metastasis Cytokines in Bone Marrow Mesenchymal Stem Cells. Biomed Res Int. 2018;2018:6565393 pubmed publisher
Zhang C, Jiang H, Wang P, Liu H, Sun X. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017;7:44708 pubmed publisher
Lei H, Li X, Jing B, Xu H, Wu Y. Human S100A7 Induces Mature Interleukin1? Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. PLoS ONE. 2017;12:e0169788 pubmed publisher
Lin X, Chen Q, Huang C, Xu X. CYLD Promotes TNF-?-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells. Mediators Inflamm. 2016;2016:1542786 pubmed
Button R, Vincent J, Strang C, Luo S. Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget. 2016;7:5157-75 pubmed publisher
Xu Y, Cheng Q, Yang B, Yu S, Xu F, Lu L, et al. Increased sCD200 Levels in Vitreous of Patients With Proliferative Diabetic Retinopathy and Its Correlation With VEGF and Proinflammatory Cytokines. Invest Ophthalmol Vis Sci. 2015;56:6565-72 pubmed publisher
Cao W, Li H, Zhang J, Li D, Acheampong D, Chen Z, et al. Periplasmic expression optimization of VEGFR2 D3 adopting response surface methodology: antiangiogenic activity study. Protein Expr Purif. 2013;90:55-66 pubmed publisher
Chen X, Wang C, Xu L, Chen X, Wang W, Yang G, et al. A laboratory evaluation of medicinal herbs used in china for the treatment of hand, foot, and mouth disease. Evid Based Complement Alternat Med. 2013;2013:504563 pubmed publisher
Chen X, Qiao H, Liu T, Yang Z, Xu L, Xu Y, et al. Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation. Antiviral Res. 2012;95:30-6 pubmed publisher
Feng R, Guo Z, Yan C, Li E, Tan R, Ge H. Anti-inflammatory flavonoids from Cryptocarya chingii. Phytochemistry. 2012;76:98-105 pubmed publisher
Jia D, Yang H, Wan L, Cheng J, Lu X. Production of bioactive, SUMO-modified, and native-like TNF-? of the rhesus monkey, Macaca mulatta, in Escherichia coli. Appl Microbiol Biotechnol. 2012;93:2345-55 pubmed publisher
Chen X, Wang Z, Yang Z, Wang J, Xu Y, Tan R, et al. Houttuynia cordata blocks HSV infection through inhibition of NF-?B activation. Antiviral Res. 2011;92:341-5 pubmed publisher
Schyns R. [Determination of the N-terminal amino acid of a protein by application of the Edman method to material fixed on polyacrylamide gel]. J Chromatogr. 1969;44:207-8 pubmed
image
image 1 :
Sino Biological 10602-HNAE image 1
product information
Catalog Number :
10602-HNAE
Product Name :
Human TNF-alpha / TNFA Protein
Product Type :
Protein
Host Species :
E. coli
Conjugation :
Native
Size :
1 mg
List Price :
1288 USD
Gene ID :
NP_000585.2
Product Description :
A DNA sequence encoding the human TNF-α soluble form (NP_000585.2) (Val 77-Leu 233) was expressed, with an initial Met at the N-terminus.
SpeciesSummary :
Human
ALTnames :
DIF,TNFA,TNF-alpha,TNFSF2,TNLG1F
Purity :
≥ 95 % as determined by SDS-PAGE, ≥ 95 % as determined by SEC-HPLC, ≥ 95% as determined by SEC-MALS(Routinely tested).
Buffer :
Lyophilized from sterile PBS, pH 7.4.
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.