product summary
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company name :
Sino Biological
product type :
protein
product name :
Human CD64 / FCGR1A Protein (His Tag)
catalog :
10256-H08H
quantity :
1 mg
price :
1926 USD
more info or order :
Sino Biological product webpage
citations: 11
Reference
Gil González L, Won K, Tawhidi Z, Cummins E, Cruz Leal Y, Tundidor Cabado Y, et al. Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP. Blood Adv. 2024;8:1869-1879 pubmed publisher
Martinez F, White M, Guillotte Blisnick M, Huon C, Boucharlat A, Agou F, et al. PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial. NPJ Vaccines. 2024;9:10 pubmed publisher
Park J, Choi H, Jung K, Lee K, Shim J, Park K, et al. Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens. Commun Biol. 2023;6:589 pubmed publisher
Anderson K, Bergonzo C, Scott K, Karageorgos I, Gallagher E, Tayi V, et al. HDX-MS and MD Simulations Provide Evidence for Stabilization of the IgG1-FcγRIa (CD64a) Immune Complex Through Intermolecular Glycoprotein Bonds. J Mol Biol. 2022;434:167391 pubmed publisher
Temming A, Bentlage A, de Taeye S, Bosman G, Lissenberg Thunnissen S, Derksen N, et al. Cross-reactivity of mouse IgG subclasses to human Fc gamma receptors: Antibody deglycosylation only eliminates IgG2b binding. Mol Immunol. 2020;127:79-86 pubmed publisher
Borghi S, Bournazos S, Thulin N, Li C, Gajewski A, Sherwood R, et al. FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies. Proc Natl Acad Sci U S A. 2020;117:12943-12951 pubmed publisher
de Taeye S, Bentlage A, Mebius M, Meesters J, Lissenberg Thunnissen S, Falck D, et al. FcγR Binding and ADCC Activity of Human IgG Allotypes. Front Immunol. 2020;11:740 pubmed publisher
de Silva S, Fromm G, Shuptrine C, Johannes K, Patel A, Yoo K, et al. CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity. Cancer Immunol Res. 2020;8:230-245 pubmed publisher
Aoyama M, Hashii N, Tsukimura W, Osumi K, Harazono A, Tada M, et al. Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies. MAbs. 2019;11:826-836 pubmed publisher
Bruggeman C, Dekkers G, Bentlage A, Treffers L, Nagelkerke S, Lissenberg Thunnissen S, et al. Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fc? Receptor Profile. J Immunol. 2017;199:204-211 pubmed publisher
Hayes J, Frostell A, Cosgrave E, Struwe W, Potter O, Davey G, et al. Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions. J Proteome Res. 2014;13:5471-85 pubmed publisher
image
image 1 :
Sino Biological 10256-H08H image 1
product information
Catalog Number :
10256-H08H
Product Name :
Human CD64 / FCGR1A Protein (His Tag)
Product Type :
Protein
Host Species :
HEK293 Cells
Conjugation :
C-His
Size :
1 mg
List Price :
1926 USD
Gene ID :
NP_000557.1
Product Description :
A DNA sequence encoding the extracellular domain of human CD64A (NP_000557.1) (Met 1-Pro 288) was expressed, fused with a polyhistidine tag at the C-terminus.
SpeciesSummary :
Human
ALTnames :
CD64/FCGR1
Purity :
≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ≥ 90 % as determined by SEC-MALS(Routinely tested).
Buffer :
Lyophilized from sterile PBS, pH 7.4.
Packaging :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
more info or order :
Sino Biological product webpage
company information
Sino Biological
Building 9, No.18 Kechuang 10th St, BDA, Beijing, 100176
marketing@sinobiological.com
https://www.sinobiological.com
86 400-890-9989
headquarters: China
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.