Human PD-L1 / B7-H1 / CD274 Protein | Sino Biological 10084-HNAH product information

product summary

company name :

Sino Biological

product type :

protein

product name :

Human PD-L1 / B7-H1 / CD274 Protein

catalog :

10084-HNAH

quantity :

1 mg

price :

2258 USD

more info or order :

Sino Biological product webpage

citations: 7

Reference
Lu T, Zhang J, Chen Q, Ni M, Zhang J, Wu Y, et al. Design, Synthesis, Evaluation, and SAR of 5-Phenylisoindoline Derivatives, a Potent Class of Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) Interaction. J Med Chem. 2025;68:7291-7312 pubmed publisher
Wang S, Kong Z, Shi Y, Shao C, Wang W, Su Z, et al. Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy. J Med Chem. 2024;67:9447-9464 pubmed publisher
Liu J, Cheng Y, Yuan L, Liu T, Ruan Y, Ren Y, et al. Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J Med Chem. 2023;66:13172-13188 pubmed publisher
Ding Z, Wang S, Shi Y, Fei X, Cheng B, Lu Y, et al. Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023;66:10364-10380 pubmed publisher
Huang S, Pan C, Lin Y, Chen M, Chen Y, Jan C, et al. BiTE-Secreting CAR-γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors. Adv Sci (Weinh). 2023;10:e2206856 pubmed publisher
Cao H, Cheng B, Liu T, Chen J. Synthesis and pharmacological evaluation of novel resorcinol biphenyl ether analogs as small molecule inhibitors of PD-1/PD-L1 with benign toxicity profiles for cancer treatment. Biochem Pharmacol. 2021;188:114522 pubmed publisher
Cheng B, Wang W, Niu X, Ren Y, Liu T, Cao H, et al. Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment. J Med Chem. 2020;63:15946-15959 pubmed publisher

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product information

Catalog Number :

10084-HNAH

Product Name :

Human PD-L1 / B7-H1 / CD274 Protein

Product Type :

Protein

Host Species :

HEK293 Cells

Conjugation :

Native

Size :

1 mg

List Price :

2258 USD

Gene ID :

NP_054862.1

Product Description :

A DNA sequence encoding the human CD274 (NP_054862.1) (Met1-Arg238) was expressed.

SpeciesSummary :

Human

ALTnames :

B7-H,B7H1,hPD-L1,PDCD1L1,PDCD1LG1,PDL1,PD-L1,B7-H1

Purity :

≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Buffer :

Lyophilized from sterile PBS, pH 7.4.

Packaging :

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Storage :

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

more info or order :

Sino Biological product webpage