Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag) | Sino Biological 10084-H02H product information

product summary

company name :

Sino Biological

product type :

protein

product name :

Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag)

catalog :

10084-H02H

quantity :

1 mg

price :

2188 USD

more info or order :

Sino Biological product webpage

citations: 14

Reference
Zhang F, Yu Q, Wu C, Sun S, Wang Y, Wang R, et al. Design, synthesis, anti-tumor activity and mechanism of novel PROTACs as degraders of PD-L1 and inhibitors of PD-1/PD-L1 interaction. Bioorg Med Chem. 2024;111:117867 pubmed publisher
Lobaina Y, Chen R, Suzarte E, Ai P, Huerta V, Musacchio A, et al. The Nucleocapsid Protein of SARS-CoV-2, Combined with ODN-39M, Is a Potential Component for an Intranasal Bivalent Vaccine with Broader Functionality. Viruses. 2024;16: pubmed publisher
Li Y, Li B, Wang Q, Zhang X, Zhang Q, Zhou X, et al. Dual targeting of TIGIT and PD-1 with a novel small molecule for cancer immunotherapy. Biochem Pharmacol. 2024;223:116162 pubmed publisher
Williams D, Cassel J, Zhu J, Yang J, de Voogd N, Matainaho T, et al. Thorectidiol A Isolated from the Marine Sponge Dactylospongia elegans Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor. J Nat Prod. 2023;86:582-588 pubmed publisher
Jeong S, Park E, Kim H, Sung E, Kim H, Jeon J, et al. Novel anti-4-1BB×PD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockade. J Immunother Cancer. 2021;9: pubmed publisher
Mair M, Pajenda S, Ilhan Mutlu A, Steindl A, Kiesel B, Widhalm G, et al. Soluble PD-L1 is associated with local and systemic inflammation markers in primary and secondary brain tumours. ESMO Open. 2020;5:e000863 pubmed publisher
Zhou X, Du J, Wang H, Chen C, Jiao L, Cheng X, et al. Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR. Cell Commun Signal. 2020;18:142 pubmed publisher
Grel H, Ratajczak K, Jakiela S, Stobiecka M. Gated Resonance Energy Transfer (gRET) Controlled by Programmed Death Protein Ligand 1. Nanomaterials (Basel). 2020;10: pubmed publisher
Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed publisher
Palaskas N, Garcia J, Shirazi R, Shin D, Puig Saus C, Braas D, et al. Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis. Cell Discov. 2019;5:62 pubmed publisher
Ramakrishnan S, Natarajan A, Chan C, Panesar P, Gambhir S. Engineering of a novel subnanomolar affinity fibronectin III domain binder targeting human programmed death-ligand 1. Protein Eng Des Sel. 2019;32:231-240 pubmed publisher
Perdomo Celis F, Feria M, Taborda N, Rugeles M. Induction of Follicular-Like CXCR5+ CD8+ T Cells by TGF-β1/IL-23 Is Limited During HIV Infection. Viral Immunol. 2019;32:278-288 pubmed publisher
Du J, Qin Y, Wu Y, Zhao W, Zhai W, Qi Y, et al. The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD). Cell Commun Signal. 2018;16:25 pubmed publisher
Munir S, Andersen G, Met O, Donia M, Frøsig T, Larsen S, et al. HLA-restricted CTL that are specific for the immune checkpoint ligand PD-L1 occur with high frequency in cancer patients. Cancer Res. 2013;73:1764-76 pubmed publisher

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product information

Catalog Number :

10084-H02H

Product Name :

Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag)

Product Type :

Protein

Host Species :

HEK293 Cells

Conjugation :

C-human IgG1-Fc

Size :

1 mg

List Price :

2188 USD

Gene ID :

NP_054862.1

Product Description :

A DNA sequence encoding the N-terminal segment (Met 1-Thr 239) of the extracellular domain of human B7-H1 (NP_054862.1) was expressed with C-terminal fused Fc region of human IgG1.

SpeciesSummary :

Human

ALTnames :

B7-H,B7H1,hPD-L1,PDCD1L1,PDCD1LG1,PDL1,PD-L1,B7-H1

Purity :

≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Buffer :

Lyophilized from sterile PBS, pH 7.4.

Packaging :

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Storage :

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

more info or order :

Sino Biological product webpage