ICK, Active | SignalChem Pharmaceuticals I01-10G product information

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product summary

company name :

SignalChem Pharmaceuticals

product type :

protein

product name :

ICK, Active

catalog :

I01-10G

quantity :

5 ug/10 ug

price :

205/295 USD

product information

Catalog Number :

I01-10G

Product Name :

ICK, Active

Product Type :

Active Kinases

Host Species :

Sf9 insect cells using baculovirus

Conjugation :

GST

Size :

5 ug/10 ug

List Price :

205/295 USD

Gene ID :

NM_014920

Product Description :

Full-length recombinant human ICK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

SpeciesSummary :

human

Background :

ICK or intestinal cell kinase belongs to a very extensive family of proteins that share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. ICK encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases (1). ICK localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. ICK purified from transfected human embryonic kidney cells undergoes autophosphorylation and phosphorylates a test protein. ICK plays a key role in development of central nervous, skeletal, and endocrine systems (2).

ALTnames :

ECO; MRK; KIAA0936; LCK2; MGC46090

Purity :

>75%

Buffer :

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Packaging :

Dry Ice

Concentration :

0.1ug/ul

Uses :

Kinase Assay, Western Blot

Application Summary :

The specific activity was determined to be 4.8 nmol/min/mg as per activity assay protocol.

Storage :

Store product at –70ºC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.