This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
DL-Thiorphan
catalog :
T6031
citations: 43
Reference
Pina M, Pati D, Hwa L, Wu S, Mahoney A, Omenyi C, et al. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrainprojections from the insular cortex. Neuropharmacology. 2020;165:107831 pubmed publisher
Varga A, Reid B, Kieffer B, Levitt E. Differential impact of two critical respiratory centres in opioid-induced respiratory depression in awake mice. J Physiol. 2020;598:189-205 pubmed publisher
Birdsong W, Jongbloets B, Engeln K, Wang D, Scherrer G, Mao T. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. elife. 2019;8: pubmed publisher
Sauter A, Mansi R, Hassiepen U, Muller L, Panigada T, Wiehr S, et al. Targeting of the Cholecystokinin-2 Receptor with the Minigastrin Analog 177Lu-DOTA-PP-F11N: Does the Use of Protease Inhibitors Further Improve In Vivo Distribution?. J Nucl Med. 2019;60:393-399 pubmed publisher
Genova R, Meyer K, Anderson M, Harper M, Pieper A. Neprilysin inhibition promotes corneal wound healing. Sci Rep. 2018;8:14385 pubmed publisher
Dong X, Gu R, Zhu X, Gan H, Liu J, Jin J, et al. Evaluating prodrug characteristics of a novel anticoagulant fusion protein neorudin, a prodrug targeting release of hirudin variant 2-Lys47 at the thrombosis site, by means of in vitro pharmacokinetics. Eur J Pharm Sci. 2018;121:166-177 pubmed publisher
Renström L, Stål P, Song Y, Forsgren S. Bilateral muscle fiber and nerve influences by TNF-alpha in response to unilateral muscle overuse - studies on TNF receptor expressions. BMC Musculoskelet Disord. 2017;18:498 pubmed publisher
Morozumi N, Sato S, Yoshida S, Harada Y, Furuya M, Minamitake Y, et al. Design and evaluation of novel natriuretic peptide derivatives with improved pharmacokinetic and pharmacodynamic properties. Peptides. 2017;97:16-21 pubmed publisher
Fernández Atucha A, Izagirre A, Fraile Bermúdez A, Kortajarena M, Larrinaga G, Martinez Lage P, et al. Sex differences in the aging pattern of renin-angiotensin system serum peptidases. Biol Sex Differ. 2017;8:5 pubmed publisher
Son S, Cha M, Choi H, Kang S, Choi H, Lee M, et al. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Autophagy. 2016;12:784-800 pubmed publisher
Doi Y, Takeuchi H, Mizoguchi H, Fukumoto K, Horiuchi H, Jin S, et al. Granulocyte-colony stimulating factor attenuates oligomeric amyloid β neurotoxicity by activation of neprilysin. PLoS ONE. 2014;9:e103458 pubmed publisher
Song Y, Stål P, Yu J, Lorentzon R, Backman C, Forsgren S. Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model. BMC Musculoskelet Disord. 2014;15:126 pubmed publisher
Mehta S, Khandelwal P, Jain V, Sihag M. A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea. J Assoc Physicians India. 2012;60:12-5 pubmed
Houde M, Jamain M, Labonte J, Desbiens L, Pejler G, Gurish M, et al. Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1. J Pharmacol Exp Ther. 2013;346:31-7 pubmed publisher
Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, et al. Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Sci Rep. 2013;3:1472 pubmed publisher
Duh D, Tanret I. [Racecadotril (Tiorfix), oral]. J Pharm Belg. 2012;:51-2 pubmed
Schreiter A, Gore C, Labuz D, Fournie Zaluski M, Roques B, Stein C, et al. Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. FASEB J. 2012;26:5161-71 pubmed publisher
Tack J. Functional diarrhea. Gastroenterol Clin North Am. 2012;41:629-37 pubmed publisher
Lopez Campos J, Gutierrez C, Calero C. The potential role of racecadotril in the treatment of diarrhea associated with roflumilast. Arch Bronconeumol. 2012;48:426 pubmed publisher
Mess J, Taillon M, Côté C, Garofolo F. Dried blood spot on-card derivatization: an alternative form of sample handling to overcome the instability of thiorphan in biological matrix. Biomed Chromatogr. 2012;26:1617-24 pubmed publisher
Jawien J, Toton Zuranska J, Gajda M, Niepsuj A, Gebska A, Kus K, et al. Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice. J Physiol Pharmacol. 2012;63:77-85 pubmed
Tampellini D, Rahman N, Lin M, Capetillo Zarate E, Gouras G. Impaired ?-amyloid secretion in Alzheimer's disease pathogenesis. J Neurosci. 2011;31:15384-90 pubmed publisher
Koh Y, Moochhala S, Bhatia M. The role of neutral endopeptidase in caerulein-induced acute pancreatitis. J Immunol. 2011;187:5429-39 pubmed publisher
Miners J, Barua N, Kehoe P, Gill S, Love S. A?-degrading enzymes: potential for treatment of Alzheimer disease. J Neuropathol Exp Neurol. 2011;70:944-59 pubmed publisher
Davies J, Chant R, Simpson S, Powell R. Routine antenatal anti-D prophylaxis--is the protection adequate?. Transfus Med. 2011;21:421-6 pubmed publisher
Cuello García C, Pacheco Alvarado K, Pérez Gaxiola G. Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems. Arch Dis Child. 2011;96:723-8 pubmed publisher
Lee J, Cheng K, Chung H, Wu H, Chen C, Cheng J. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Horm Metab Res. 2011;43:489-93 pubmed publisher
Lehert P, Chéron G, Calatayud G, Cezard J, Castrellón P, Garcia J, et al. Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. Dig Liver Dis. 2011;43:707-13 pubmed publisher
Ali N, Elghobashy M, Mahmoud M, Mohammed M. Spectrophotometric and spectrofluorimetric methods for determination of Racecadotril. Pak J Pharm Sci. 2011;24:19-23 pubmed
Subiran N, Pinto F, Agirregoitia E, Candenas L, Irazusta J. Control of APN/CD13 and NEP/CD10 on sperm motility. Asian J Androl. 2010;12:899-902 pubmed publisher
Li W, Wu Y, Min F, Li Z, Huang J, Huang R. A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-?42 and thiorphan. Metab Brain Dis. 2010;25:277-84 pubmed publisher
Hofmann R. Remarks and questions on the article "Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes". Eur J Clin Pharmacol. 2010;66:839; author reply 841-2 pubmed publisher
Inbar D, Belinson H, Rosenman H, Michaelson D. Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade. Neurodegener Dis. 2010;7:16-23 pubmed publisher
Wu H, Chang C, Cheng K, Chang C, Yeh C, Cheng J. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010;42:261-7 pubmed publisher
Mohamed A, Fouad M, Hasan M, Abdel Razeq S, Elsherif Z. Stability-indicating methods for the determination of racecadotril in the presence of its degradation products. Biosci Trends. 2009;3:247-52 pubmed
Matsumoto T, Ozawa Y, Taguchi K, Kobayashi T, Kamata K. Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction. Peptides. 2010;31:346-53 pubmed publisher
Dubrovskaia N, Nalivaeva N, Plesneva S, Feponova A, Turner A, Zhuravin I. [Changes in the activity of amyloid-degrading metallopeptidases leads to disruption of memory in rats]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2009;59:630-8 pubmed
Abramov E, Dolev I, Fogel H, Ciccotosto G, Ruff E, Slutsky I. Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci. 2009;12:1567-76 pubmed publisher
Olimpieri F, Tambaro S, Fustero S, Lazzari P, Sánchez Roselló M, Pani L, et al. Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors. Bioorg Med Chem Lett. 2009;19:4715-9 pubmed publisher
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Gabrilovac J, Cupic B, Breljak D, Zekusić M, Boranic M. Expression of CD13/aminopeptidase N and CD10/neutral endopeptidase on cultured human keratinocytes. Immunol Lett. 2004;91:39-47 pubmed
Antezana M, Sullivan S, Usui M, Gibran N, Spenny M, Larsen J, et al. Neutral endopeptidase activity is increased in the skin of subjects with diabetic ulcers. J Invest Dermatol. 2002;119:1400-4 pubmed
Roques B, Fournie Zaluski M, Soroca E, Lecomte J, Malfroy B, Llorens C, et al. The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice. Nature. 1980;288:286-8 pubmed
product information
Catalog Number :
T6031
Product Name :
DL-Thiorphan
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (TLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA