product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Plakoglobin (Catenin γ) antibody produced in mouse
catalog :
P8087
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
15F11
reactivity :
human, mouse, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5a
Richardson R, Mitchell K, Hammond N, Mollo M, Kouwenhoven E, Wyatt N, et al. p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017;13:e1006828 pubmed publisher
  • immunocytochemistry; human
Crespi A, Bertoni A, Ferrari I, Padovano V, Della Mina P, Berti E, et al. POF1B localizes to desmosomes and regulates cell adhesion in human intestinal and keratinocyte cell lines. J Invest Dermatol. 2015;135:192-201 pubmed publisher
Van Opbergen C, Noorman M, Pfenniger A, Copier J, Vermij S, Li Z, et al. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. Int J Mol Sci. 2019;20: pubmed publisher
Begay R, Graw S, Sinagra G, Asimaki A, Rowland T, Slavov D, et al. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018;4:504-514 pubmed publisher
Chelko S, Asimaki A, Andersen P, Bedja D, Amat Alarcon N, Demazumder D, et al. Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016;1: pubmed publisher
Kant S, Krusche C, Gaertner A, Milting H, Leube R. Loss of plakoglobin immunoreactivity in intercalated discs in arrhythmogenic right ventricular cardiomyopathy: protein mislocalization versus epitope masking. Cardiovasc Res. 2016;109:260-71 pubmed publisher
Rasmussen T, Nissen P, Palmfeldt J, Gehmlich K, Dalager S, Jensen U, et al. Truncating plakophilin-2 mutations in arrhythmogenic cardiomyopathy are associated with protein haploinsufficiency in both myocardium and epidermis. Circ Cardiovasc Genet. 2014;7:230-40 pubmed publisher
Cooksley Decasper S, Reiser H, Thommen D, Biedermann B, Neidhart M, Gawinecka J, et al. Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. PLoS ONE. 2012;7:e47985 pubmed publisher
Tomlinson D, Baxter E, Loadman P, Hull M, Knowles M. FGFR1-induced epithelial to mesenchymal transition through MAPK/PLC?/COX-2-mediated mechanisms. PLoS ONE. 2012;7:e38972 pubmed publisher
Li Z, Lock J, Olofsson H, Kowalewski J, Teller S, Liu Y, et al. Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover. Mol Biol Cell. 2010;21:3317-29 pubmed publisher
Geisler S, Green K, Isom L, Meshinchi S, Martens J, Delmar M, et al. Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes. J Biomed Biotechnol. 2010;2010:624719 pubmed publisher
Srivastava S, Ramdass B, Nagarajan S, Rehman M, Mukherjee G, Krishna S. Notch1 regulates the functional contribution of RhoC to cervical carcinoma progression. Br J Cancer. 2010;102:196-205 pubmed publisher
Palka H, Park M, Tonks N. Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem. 2003;278:5728-35 pubmed
Relova A, Kampf C, Roomans G. Effects of Th-2 type cytokines on human airway epithelial cells: interleukins-4, -5, and -13. Cell Biol Int. 2001;25:563-6 pubmed
Lou P, Chen W, Lin C, Chen H, Wu J. Taxol reduces cytosolic E-cadherin and beta-catenin levels in nasopharyngeal carcinoma cell line TW-039: cross-talk between the microtubule- and actin-based cytoskeletons. J Cell Biochem. 2000;79:542-56 pubmed
Thoreson M, Anastasiadis P, Daniel J, Ireton R, Wheelock M, Johnson K, et al. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J Cell Biol. 2000;148:189-202 pubmed
Johnson K, Lewis J, Li D, Wahl J, Soler A, Knudsen K, et al. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res. 1993;207:252-60 pubmed
Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, Miyazawa K, et al. Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes Commun. 1994;1:295-305 pubmed
Aberle H, Bierkamp C, Torchard D, Serova O, Wagner T, Natt E, et al. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc Natl Acad Sci U S A. 1995;92:6384-8 pubmed
Reynolds A, Daniel J, McCrea P, Wheelock M, Wu J, Zhang Z. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol. 1994;14:8333-42 pubmed
product information
Product No. :
P8087
Product Name :
Monoclonal Anti-Plakoglobin (Catenin γ) antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
15F11
Applications/Description :
Suitable for immunocytochemistry using cultured cells; western blot: 1:2,000 using cultured MDBK cells; microarray; indirect immunofluorescence: 1:1,000 using cultured MDBK cells; immunoprecipitation (IP); immunohistochemistry (frozen sections
Species Reactivity :
human, bovine, canine
Isotype :
IgG1
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA