This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Pirenzepine dihydrochloride
catalog :
P7412
citations: 28
Reference
Migita K, Nishimura A, Eto F, Koga K, Matsumoto T, Terada K, et al. Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice. J Pharmacol Sci. 2020;142:50-59 pubmed publisher
Ross J, Bendahmane M, Fletcher M. Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning. Front Behav Neurosci. 2019;13:164 pubmed publisher
Muramatsu I, Uwada J, Yoshiki H, Sada K, Lee K, Yazawa T, et al. Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer's disease drugs. J Neurochem. 2019;149:605-623 pubmed publisher
Koga K, Matsuzaki Y, Migita K, Shimoyama S, Eto F, Nakagawa T, et al. Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats. Brain Res. 2019;1704:187-195 pubmed publisher
Sabbir M, Calcutt N, Fernyhough P. Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons. Front Neurosci. 2018;12:402 pubmed publisher
Deckmann K, Rafiq A, Erdmann C, Illig C, Durschnabel M, Wess J, et al. Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback. FASEB J. 2018;32:2903-2910 pubmed publisher
Cui E, Strowbridge B. Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells. J Neurosci. 2018;38:423-440 pubmed publisher
Nagashima F, Nishiyama R, Iwao B, Kawai Y, Ishii C, Yamanaka T, et al. Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets. Biomol Ther (Seoul). 2017;: pubmed publisher
Iwase M, Nishimura Y, Kurata N, Namba H, Hirai T, Kiuchi Y. Inhibitory Effects of Gastrointestinal Drugs on CYP Activities in Human Liver Microsomes. Biol Pharm Bull. 2017;40:1654-1660 pubmed publisher
Aydinoglu F, Dalkir F, Demirbag H, Ogulener N. The interaction of l-cysteine/H2S pathway and muscarinic acetylcholine receptors (mAChRs) in mouse corpus cavernosum. Nitric Oxide. 2017;70:51-58 pubmed publisher
Tsentsevitsky A, Kovyazina I, Nurullin L, Nikolsky E. Muscarinic cholinoreceptors (M1-, M2-, M3- and M4-type) modulate the acetylcholine secretion in the frog neuromuscular junction. Neurosci Lett. 2017;649:62-69 pubmed publisher
Nagashima H, Shinoda M, Honda K, Kamio N, Watanabe M, Suzuki T, et al. CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice. Mol Pain. 2017;13:1744806916689269 pubmed publisher
Filatova T, Naumenko N, Galenko Yaroshevsky P, Abramochkin D. M3 cholinoreceptors alter electrical activity of rat left atrium via suppression of L-type Ca2+ current without affecting K+ conductance. J Physiol Biochem. 2017;73:167-174 pubmed publisher
Obis T, Hurtado E, Nadal L, Tomàs M, Priego M, Simon A, et al. The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction. Mol Brain. 2015;8:80 pubmed publisher
DiPatrizio N, Igarashi M, Narayanaswami V, Murray C, Gancayco J, Russell A, et al. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. Am J Physiol Regul Integr Comp Physiol. 2015;309:R805-13 pubmed publisher
Santafe M, Priego M, Obis T, Garcia N, Tomas M, Lanuza M, et al. Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse. Eur J Neurosci. 2015;42:1775-87 pubmed publisher
Cui Y, Paille V, Xu H, Genet S, Delord B, Fino E, et al. Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity. J Physiol. 2015;593:2833-49 pubmed publisher
Witkin J, Overshiner C, Li X, Catlow J, Wishart G, Schober D, et al. M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine. J Pharmacol Exp Ther. 2014;351:448-56 pubmed publisher
Wu W, Li H, Liu Y, Huang X, Chen L, Zhai H. Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats. Psychopharmacology (Berl). 2014;231:4109-18 pubmed publisher
Park C, Kim P, Lee S, Yoon M. Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test. Korean J Anesthesiol. 2013;64:152-60 pubmed publisher
Lee B, Gauna A, Perez G, Park Y, Pauley K, Kawai T, et al. Autoantibodies against muscarinic type 3 receptor in Sjögren's syndrome inhibit aquaporin 5 trafficking. PLoS ONE. 2013;8:e53113 pubmed publisher
Tozzi A, de Iure A, Marsili V, Romano R, Tantucci M, Di Filippo M, et al. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS ONE. 2012;7:e38312 pubmed publisher
Milara J, Serrano A, Peiró T, Gavaldá A, Miralpeix M, Morcillo E, et al. Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax. 2012;67:229-37 pubmed publisher
Almasieh M, Zhou Y, Kelly M, Casanova C, Di Polo A. Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Cell Death Dis. 2010;1:e27 pubmed publisher
Pelat M, Lazartigues E, Tran M, Gharib C, Montastruc J, Montastruc P, et al. Characterization of the central muscarinic cholinoceptors involved in the cholinergic pressor response in anesthetized dogs. Eur J Pharmacol. 1999;379:117-24 pubmed
Elhusseiny A, Cohen Z, Olivier A, Stanimirovic D, Hamel E. Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization. J Cereb Blood Flow Metab. 1999;19:794-802 pubmed
Aramakis V, Bandrowski A, Ashe J. Role of muscarinic receptors, G-proteins, and intracellular messengers in muscarinic modulation of NMDA receptor-mediated synaptic transmission. Synapse. 1999;32:262-75 pubmed
Rosati A, Guarnieri E, Avignone E, Cherubini E, Cattaneo A, Traversa U. Increased density of M1 receptors in the hippocampus of juvenile rats chronically deprived of NGF. Brain Res. 1999;815:185-91 pubmed
product information
Catalog Number :
P7412
Product Name :
Pirenzepine dihydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (TLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA