product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Protein Kinase C (PKC) antibody produced in mouse
catalog :
P5704
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MC5
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 60
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 6c
Orhan E, Neuillé M, de Sousa Dias M, Pugliese T, Michiels C, Condroyer C, et al. A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency. Int J Mol Sci. 2021;22: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 1c
Nagy J, Ebbinghaus B, Hoon M, Sinha R. GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons. elife. 2021;10: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; loading ...; fig 1b
Wakeham C, Ren G, Morgans C. Expression and distribution of trophoblast glycoprotein in the mouse retina. J Comp Neurol. 2020;528:1660-1671 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4a
Fairchild C, Hino K, Han J, Miltner A, Peinado Allina G, Brown C, et al. RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018;145: pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; tbl 1
Hannibal J, Christiansen A, Heegaard S, Fahrenkrug J, Kiilgaard J. Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity. J Comp Neurol. 2017;525:1934-1961 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 2
Maxeiner S, Luo F, Tan A, Schmitz F, Südhof T. How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release. EMBO J. 2016;35:1098-114 pubmed publisher
  • western blot; mouse; 1:400
Ho T, Vessey K, Fletcher E. Immunolocalization of the P2X4 receptor on neurons and glia in the mammalian retina. Neuroscience. 2014;277:55-71 pubmed publisher
  • western blot; human; fig 1
Guardia Laguarta C, Area Gomez E, Rüb C, Liu Y, Magrane J, Becker D, et al. ?-Synuclein is localized to mitochondria-associated ER membranes. J Neurosci. 2014;34:249-59 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Yvert G, Lindenberg K, Picaud S, Landwehrmeyer G, Sahel J, Mandel J. Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Hum Mol Genet. 2000;9:2491-506 pubmed
Li Y, Shi S, Xia F, Shan C, Ha Y, Zou J, et al. Zika virus induces neuronal and vascular degeneration in developing mouse retina. Acta Neuropathol Commun. 2021;9:97 pubmed publisher
Falasconi A, Biagioni M, Novelli E, Piano I, Gargini C, Strettoi E. Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP. Front Neurosci. 2019;13:991 pubmed publisher
Care R, Kastner D, De la Huerta I, Pan S, Khoche A, Della Santina L, et al. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Rep. 2019;27:2171-2183.e5 pubmed publisher
Cho S, Cho H, Woo K, Jeong J, Lim J, Park S, et al. Nelumbo nucifera Receptaculum Extract Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy. Molecules. 2019;24: pubmed publisher
Guo Y, Guo C, Ha W, Ding Z. Carnosine improves diabetic retinopathy via the MAPK/ERK pathway. Exp Ther Med. 2019;17:2641-2647 pubmed publisher
Li X, Zhang W. Influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects on rats with neuropathic pain and expression of protein kinase C in the spinal dorsal horn. Exp Ther Med. 2018;16:3835-3840 pubmed publisher
Takeuchi H, Horie S, Moritoh S, Matsushima H, Hori T, Kimori Y, et al. Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. Biomed Res Int. 2018;2018:2963232 pubmed publisher
Zhou Y, Wei R, Zhang L, Chen Y, Lu S, Liang C, et al. Rb is required for retinal angiogenesis and lamination. Cell Death Dis. 2018;9:370 pubmed publisher
Cammalleri M, Locri F, Catalani E, Filippi L, Cervia D, Dal Monte M, et al. The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy. Front Cell Neurosci. 2017;11:395 pubmed publisher
Clements R, Turk R, Campbell K, Wright K. Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J Neurosci. 2017;37:8559-8574 pubmed publisher
Gargini C, Novelli E, Piano I, Biagioni M, Strettoi E. Pattern of retinal morphological and functional decay in a light-inducible, rhodopsin mutant mouse. Sci Rep. 2017;7:5730 pubmed publisher
Park K, Randazzo G, Jones K, Brzezinski J. Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017;58:1137-1150 pubmed publisher
de Araujo G, Rabelo A, Meira J, Rossoni Júnior J, Castro Borges W, Guerra Sa R, et al. Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phox phosphorylation of NADPH oxidase in SK Hep-1 cells. Exp Biol Med (Maywood). 2017;242:333-343 pubmed publisher
Guadagni V, Cerri C, Piano I, Novelli E, Gargini C, Fiorentini C, et al. The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa. Sci Rep. 2016;6:35919 pubmed publisher
Esquiva G, Avivi A, Hannibal J. Non-image Forming Light Detection by Melanopsin, Rhodopsin, and Long-Middlewave (L/W) Cone Opsin in the Subterranean Blind Mole Rat, Spalax Ehrenbergi: Immunohistochemical Characterization, Distribution, and Connectivity. Front Neuroanat. 2016;10:61 pubmed publisher
Yu Z, Li D, Huang X, Xing X, Yu R, Li Z, et al. Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through the GPCR/PKC and PKA pathways. Int J Mol Med. 2016;37:468-74 pubmed publisher
Neuillé M, Morgans C, Cao Y, Orhan E, Michiels C, Sahel J, et al. LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur J Neurosci. 2015;42:1966-75 pubmed publisher
Greferath U, Vessey K, Jobling A, Mills S, Bui B, He Z, et al. The role of histamine in the retina: studies on the Hdc knockout mouse. PLoS ONE. 2014;9:e116025 pubmed publisher
Barone I, Novelli E, Strettoi E. Long-term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment. Mol Vis. 2014;20:1545-56 pubmed
Ramakrishnan H, Dhingra A, Tummala S, Fina M, Li J, Lyubarsky A, et al. Differential function of Gγ13 in rod bipolar and ON cone bipolar cells. J Physiol. 2015;593:1531-50 pubmed publisher
Sun H, Lu L, Zuo Y, Wang Y, Jiao Y, Zeng W, et al. Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nat Commun. 2014;5:4980 pubmed publisher
Kuramoto K, Sakai F, Yoshinori N, Nakamura T, Wakabayashi S, Kojidani T, et al. Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction. Mol Cell Biol. 2014;34:2721-31 pubmed
Vessey K, Greferath U, Aplin F, Jobling A, Phipps J, Ho T, et al. Adenosine triphosphate-induced photoreceptor death and retinal remodeling in rats. J Comp Neurol. 2014;522:2928-50 pubmed publisher
Brzezinski J, Uoon Park K, Reh T. Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Dev Biol. 2013;384:194-204 pubmed publisher
Tran T, Bedecarrats G, Choh V. Inner retinal cell development is impaired in Smoky Joe chickens. Poult Sci. 2013;92:1322-30 pubmed publisher
Chen D, Chen Y, Forrest D, Bremner R. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ. 2013;20:931-40 pubmed publisher
Nivison Smith L, Collin S, Zhu Y, Ready S, Acosta M, Hunt D, et al. Retinal amino acid neurochemistry of the southern hemisphere lamprey, Geotria australis. PLoS ONE. 2013;8:e58406 pubmed publisher
Nivison Smith L, Sun D, Fletcher E, Marc R, Kalloniatis M. Mapping kainate activation of inner neurons in the rat retina. J Comp Neurol. 2013;521:2416-38 pubmed publisher
Barone I, Novelli E, Piano I, Gargini C, Strettoi E. Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa. PLoS ONE. 2012;7:e50726 pubmed publisher
Hilgen G, Huebner A, Tanimoto N, Sothilingam V, Seide C, Garcia Garrido M, et al. Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina. PLoS ONE. 2012;7:e46155 pubmed publisher
Haurigot V, Villacampa P, Ribera A, Bosch A, Ramos D, Ruberte J, et al. Long-term retinal PEDF overexpression prevents neovascularization in a murine adult model of retinopathy. PLoS ONE. 2012;7:e41511 pubmed publisher
Prasov L, Glaser T. Pushing the envelope of retinal ganglion cell genesis: context dependent function of Math5 (Atoh7). Dev Biol. 2012;368:214-30 pubmed publisher
Omori Y, Araki F, Chaya T, Kajimura N, Irie S, Terada K, et al. Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells. J Neurosci. 2012;32:6126-37 pubmed publisher
Restani L, Novelli E, Bottari D, Leone P, Barone I, Galli Resta L, et al. Botulinum neurotoxin A impairs neurotransmission following retrograde transynaptic transport. Traffic. 2012;13:1083-9 pubmed publisher
Vessey K, Fletcher E. Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PLoS ONE. 2012;7:e29990 pubmed publisher
Puthussery T, Gayet Primo J, Taylor W. Carbonic anhydrase-related protein VIII is expressed in rod bipolar cells and alters signaling at the rod bipolar to AII-amacrine cell synapse in the mammalian retina. Eur J Neurosci. 2011;34:1419-31 pubmed publisher
Ball S, McEnery M, Yunker A, Shin H, Gregg R. Distribution of voltage gated calcium channel ? subunits in the mouse retina. Brain Res. 2011;1412:1-8 pubmed publisher
Brzezinski J, Kim E, Johnson J, Reh T. Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011;138:3519-31 pubmed publisher
Yu J, Lei K, Zhou M, Craft C, Xu G, Xu T, et al. KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011;20:1061-73 pubmed publisher
Gálvez M. Protein kinase C inhibitors in the treatment of diabetic retinopathy. Review. Curr Pharm Biotechnol. 2011;12:386-91 pubmed
Hara A, Taguchi A, Aoki H, Hatano Y, Niwa M, Yamada Y, et al. Folate antagonist, methotrexate induces neuronal differentiation of human embryonic stem cells transplanted into nude mouse retina. Neurosci Lett. 2010;477:138-43 pubmed publisher
Sulaiman P, Fina M, Feddersen R, Vardi N. Ret-PCP2 colocalizes with protein kinase C in a subset of primate ON cone bipolar cells. J Comp Neurol. 2010;518:1098-112 pubmed publisher
Brzezinski J, Lamba D, Reh T. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010;137:619-29 pubmed publisher
Dhingra A, Sulaiman P, Xu Y, Fina M, Veh R, Vardi N. Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse. J Comp Neurol. 2008;510:484-96 pubmed publisher
Hara A, Aoki H, Taguchi A, Niwa M, Yamada Y, Kunisada T, et al. Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter. Stem Cells Dev. 2008;17:619-27 pubmed publisher
Cangiano L, Gargini C, Della Santina L, Demontis G, Cervetto L. High-pass filtering of input signals by the Ih current in a non-spiking neuron, the retinal rod bipolar cell. PLoS ONE. 2007;2:e1327 pubmed
Joselevitch C, Klooster J, Kamermans M. Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina. Cell Tissue Res. 2007;330:389-403 pubmed
Dmitrieva N, Strang C, Keyser K. Expression of alpha 7 nicotinic acetylcholine receptors by bipolar, amacrine, and ganglion cells of the rabbit retina. J Histochem Cytochem. 2007;55:461-76 pubmed
Gargini C, Terzibasi E, Mazzoni F, Strettoi E. Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study. J Comp Neurol. 2007;500:222-38 pubmed
Hara A, Niwa M, Kunisada T, Yoshimura N, Katayama M, Kozawa O, et al. Embryonic stem cells are capable of generating a neuronal network in the adult mouse retina. Brain Res. 2004;999:216-21 pubmed
Young S, Rothbard J, Parker P. A monoclonal antibody recognising the site of limited proteolysis of protein kinase C. Inhibition of down-regulation in vivo. Eur J Biochem. 1988;173:247-52 pubmed
product information
Product No. :
P5704
Product Name :
Monoclonal Anti-Protein Kinase C (PKC) antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
MC5
Applications/Description :
Suitable for immunohistochemistry (frozen sections); western blot: 1:500 using rat brain cytosol preparation; microarray; immunoprecipitation (IP)
Species Reactivity :
mouse, human, bovine, rat
Isotype :
IgG2a
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA