This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Thyrotropin releasing hormone
catalog :
P1319
citations: 94
Reference
Hodge E, Kowalski A, Torcivia C, Lindborg S, Stefanovski D, HART K, et al. Effect of thyrotropin-releasing hormone stimulation testing on the oral sugar test in horses when performed as a combined protocol. J Vet Intern Med. 2019;33:2272-2279 pubmed publisher
Orso C, Moraes M, Aristimunha P, Della M, Butzen M, Krás R, et al. Effect of early feed restriction programs and genetic strain on humoral immune response production in broiler chickens. Poult Sci. 2019;98:172-178 pubmed publisher
Turgeon M, Silander T, Doycheva D, Liao X, Rigden M, Ongaro L, et al. TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice. Endocrinology. 2017;158:815-830 pubmed publisher
Zhang L, Yang J, Tian Y, Guo H, Zhang Y. Beneficial Effects of Hypoxic Preconditioning on Human Umbilical Cord Mesenchymal Stem Cells. Chin J Physiol. 2015;58:343-53 pubmed publisher
Dehigaspitiya D, Anglin B, Smith K, Weber C, Lynch R, Mash E. Linear scaffolds for multivalent targeting of melanocortin receptors. Org Biomol Chem. 2015;13:11507-17 pubmed publisher
Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, et al. IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes. Biol Chem. 2016;397:45-55 pubmed publisher
Fu S, Wang H, Wang F, Huang M, Deng L, Zhang X, et al. Clinicopathologic characteristics and therapeutic responses of Chinese patients with non-small cell lung cancer who harbor an anaplastic lymphoma kinase rearrangement. Chin J Cancer. 2015;34:404-12 pubmed publisher
Fernández Marcelo T, Gómez A, Pascua I, de Juan C, Head J, Hernando F, et al. Telomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status. J Exp Clin Cancer Res. 2015;34:78 pubmed publisher
Meena C, Thakur A, Nandekar P, Sangamwar A, Sharma S, Jain R. Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice. Bioorg Med Chem. 2015;23:5641-53 pubmed publisher
Lisboa P, Conceição E, de Oliveira E, Moura E. Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. J Endocrinol. 2015;226:219-26 pubmed publisher
Demont E, Chung C, Furze R, Grandi P, Michon A, Wellaway C, et al. Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J Med Chem. 2015;58:5649-73 pubmed publisher
Choi J, Kim J, Kim T, Park J, Lee J, Kim H, et al. TRH and TRH receptor system in the basolateral amygdala mediate stress-induced depression-like behaviors. Neuropharmacology. 2015;97:346-56 pubmed publisher
Shen Y, Xu S, He D. A Novel Europium Chelate Coated Nanosphere for Time-Resolved Fluorescence Immunoassay. PLoS ONE. 2015;10:e0129689 pubmed publisher
Zhao X, Ueda Y, Kajigaya S, Alaks G, Desierto M, Townsley D, et al. Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus. Gene. 2015;568:8-18 pubmed publisher
Contreras J, Palanichamy J, Tran T, Fernando T, Rodríguez Malavé N, Goswami N, et al. MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1. Oncotarget. 2015;6:11023-37 pubmed
Trochet D, Mergui X, Ivkovic I, Porreca R, Gerbault Seureau M, Sidibe A, et al. Telomere regulation during ageing and tumorigenesis of the grey mouse lemur. Biochimie. 2015;113:100-10 pubmed publisher
Liang Y, Meggo R, Hu D, Schnoor J, Mattes T. Microbial community analysis of switchgrass planted and unplanted soil microcosms displaying PCB dechlorination. Appl Microbiol Biotechnol. 2015;99:6515-26 pubmed publisher
Elshan N, Jayasundera T, Weber C, Lynch R, Mash E. Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor. Bioorg Med Chem. 2015;23:1841-8 pubmed publisher
Tzur Balter A, Shatsberg Z, Beckerman M, Segal E, Artzi N. Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues. Nat Commun. 2015;6:6208 pubmed publisher
Lisboa P, de Oliveira E, Manhães A, Santos Silva A, Pinheiro C, Younes Rapozo V, et al. Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny. J Endocrinol. 2015;224:315-25 pubmed publisher
Puissant M, Echert A, Yang C, Mouradian G, Novotny T, Liu P, et al. RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO₂ insensitive brown Norway rat. J Physiol. 2015;593:415-30 pubmed publisher
Breit A, Besik V, Solinski H, Muehlich S, Glas E, Yarwood S, et al. Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation. Mol Endocrinol. 2015;29:445-59 pubmed publisher
Rane G, Koh W, Kanchi M, Wang R, Yuan J, Wang X. Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population. Rejuvenation Res. 2015;18:203-10 pubmed publisher
Steenweg de Graaff J, Tiemeier H, Basten M, Rijlaarsdam J, Demmelmair H, Koletzko B, et al. Maternal LC-PUFA status during pregnancy and child problem behavior: the Generation R Study. Pediatr Res. 2015;77:489-97 pubmed publisher
Elshan N, Jayasundera T, Anglin B, Weber C, Lynch R, Mash E. Trigonal scaffolds for multivalent targeting of melanocortin receptors. Org Biomol Chem. 2015;13:1778-91 pubmed publisher
Pascua I, Fernandez Marcelo T, Sánchez Pernaute A, de Juan C, Head J, Torres García A, et al. Prognostic value of telomere function in gastric cancers with and without microsatellite instability. Eur J Gastroenterol Hepatol. 2015;27:162-9 pubmed publisher
Waniek A, Hartlage Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth H, et al. Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. Biochim Biophys Acta. 2015;1852:146-55 pubmed publisher
Jin J, Hashizume T. Effects of hypothalamic dopamine on growth hormone-releasing hormone-induced growth hormone secretion and thyrotropin-releasing hormone-induced prolactin secretion in goats. Anim Sci J. 2015;86:634-40 pubmed publisher
Anderson S, Lee I, Ebeling C, Stephenson D, Schweitzer K, Baxter D, et al. Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome. 2015;26:80-93 pubmed publisher
Myers E, Siff L, Osmundsen B, Geller E, Matthews C. Differences in recurrent prolapse at 1 year after total vs supracervical hysterectomy and robotic sacrocolpopexy. Int Urogynecol J. 2015;26:585-9 pubmed publisher
Schuman M, Peres Diaz L, Landa M, Toblli J, Cao G, Alvarez A, et al. Thyrotropin-releasing hormone overexpression induces structural changes of the left ventricle in the normal rat heart. Am J Physiol Heart Circ Physiol. 2014;307:H1667-74 pubmed publisher
Rashid Khan M, Ahsan H, Siddiqui S, Siddiqui W. Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats. Ren Fail. 2015;37:136-43 pubmed publisher
Macchia E, Lombardi M, Raffaelli V, Piaggi P, Macchia L, Scattina I, et al. Clinical and genetic characteristics of a large monocentric series of patients affected by thyroid hormone (Th) resistance and suggestions for differential diagnosis in patients without mutation of Th receptor β. Clin Endocrinol (Oxf). 2014;81:921-8 pubmed publisher
Mytych J, Lewinska A, Bielak Zmijewska A, Grabowska W, Zebrowski J, Wnuk M. Nanodiamond-mediated impairment of nucleolar activity is accompanied by oxidative stress and DNMT2 upregulation in human cervical carcinoma cells. Chem Biol Interact. 2014;220:51-63 pubmed publisher
Chausse B, Solon C, Caldeira da Silva C, Masselli Dos Reis I, Manchado Gobatto F, Gobatto C, et al. Intermittent fasting induces hypothalamic modifications resulting in low feeding efficiency, low body mass and overeating. Endocrinology. 2014;155:2456-66 pubmed publisher
Xia T, Zhang Q, Xiao Y, Wang C, Yu J, Liu H, et al. CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid. Int J Obes (Lond). 2015;39:105-13 pubmed publisher
Uribe R, Jaimes Hoy L, Ramírez Martínez C, García Vázquez A, Romero F, Cisneros M, et al. Voluntary exercise adapts the hypothalamus-pituitary-thyroid axis in male rats. Endocrinology. 2014;155:2020-30 pubmed publisher
Aréchiga Ceballos F, Alvarez Salas E, Matamoros Trejo G, Amaya M, García Luna C, de Gortari P. Pro-TRH and pro-CRF expression in paraventricular nucleus of small litter-reared fasted adult rats. J Endocrinol. 2014;221:77-88 pubmed publisher
Crowther C, Alfirevic Z, Han S, Haslam R. Thyrotropin-releasing hormone added to corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst Rev. 2013;:CD000019 pubmed publisher
Vidali S, Knuever J, Lerchner J, Giesen M, Biro T, Klinger M, et al. Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles. J Invest Dermatol. 2014;134:33-42 pubmed publisher
Luo L, Luo J, Jackson I. Tripeptide amide L-pyroglutamyl-histidyl-L-prolineamide (L-PHP-thyrotropin-releasing hormone, TRH) promotes insulin-producing cell proliferation. Curr Aging Sci. 2013;6:8-13 pubmed
Jain S, Zelena D. Role of ionotropic glutamate receptors in the control of prolactin secretion by other neurotransmitters and neuropeptides at the level of the pituitary. Endocr Regul. 2013;47:65-74 pubmed
Zhang L, Kolaj M, Renaud L. GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons. Neuropharmacology. 2013;72:106-15 pubmed publisher
Yavuz S, Linderman J, Smith S, Zhao X, Pucino F, Celi F. The dynamic pituitary response to escalating-dose TRH stimulation test in hypothyroid patients treated with liothyronine or levothyroxine replacement therapy. J Clin Endocrinol Metab. 2013;98:E862-6 pubmed publisher
Fonseca T, Correa Medina M, Campos M, Wittmann G, Werneck de Castro J, Arrojo e Drigo R, et al. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013;123:1492-500 pubmed publisher
Kamath J. Cancer-related fatigue, inflammation and thyrotropin-releasing hormone. Curr Aging Sci. 2012;5:195-202 pubmed
El Yamani F, Yon L, Guérin M, El Ouezzani S, Alaoui A, Chartrel N, et al. Immunocytochemical distribution of EM66 within the hypothalamic parvocellular paraventricular nucleus: colocalization with CRH and TRH but no plasticity related to acute stress and thyroidectomy in the rat. Regul Pept. 2013;182:28-34 pubmed publisher
Cyr N, Toorie A, Steger J, Sochat M, Hyner S, Perello M, et al. Mechanisms by which the orexigen NPY regulates anorexigenic ?-MSH and TRH. Am J Physiol Endocrinol Metab. 2013;304:E640-50 pubmed publisher
Browning K, Babic T, Holmes G, Swartz E, Travagli R. A critical re-evaluation of the specificity of action of perivagal capsaicin. J Physiol. 2013;591:1563-80 pubmed publisher
Boelen A, Kwakkel J, Fliers E. Thyroid hormone receptors in health and disease. Minerva Endocrinol. 2012;37:291-304 pubmed
Hawryluk J, Moreira T, Takakura A, Wenker I, Tzingounis A, Mulkey D. KCNQ channels determine serotonergic modulation of ventral surface chemoreceptors and respiratory drive. J Neurosci. 2012;32:16943-52 pubmed publisher
Brod S, Bauer V. Ingested (oral) thyrotropin releasing factor (TRH) inhibits EAE. Cytokine. 2013;61:323-8 pubmed publisher
Gotoh K, Masaki T, Chiba S, Ando H, Shimasaki T, Mitsutomi K, et al. Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior. J Neurochem. 2013;124:90-9 pubmed publisher
Mijiddorj T, Kanasaki H, Unurjargal S, Oride A, Purwana I, Miyazaki K. Prolonged stimulation with thyrotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide desensitize their receptor functions in prolactin-producing GH3 cells. Mol Cell Endocrinol. 2013;365:139-45 pubmed publisher
Sárvári A, Farkas E, Kádár A, Zséli G, Fuzesi T, Lechan R, et al. Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus. Brain Res. 2012;1488:72-80 pubmed publisher
Chiappini F, Ramadoss P, Vella K, Cunha L, Ye F, Stuart R, et al. Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus. Mol Cell Endocrinol. 2013;365:84-94 pubmed publisher
Carbone D, Zuloaga D, Lacagnina A, Handa R. Prepro-thyrotropin releasing hormone expressing neurons in the juxtaparaventricular region of the lateral hypothalamus are activated by leptin and altered by prenatal glucocorticoid exposure. Brain Res. 2012;1477:19-26 pubmed publisher
Gutiérrez Mariscal M, Sanchez E, García Vázquez A, Rebolledo Solleiro D, Charli J, Joseph Bravo P. Acute response of hypophysiotropic thyrotropin releasing hormone neurons and thyrotropin release to behavioral paradigms producing varying intensities of stress and physical activity. Regul Pept. 2012;179:61-70 pubmed publisher
Brown W, Gillum M, Lee H, Camporez J, Zhang X, Jeong J, et al. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proc Natl Acad Sci U S A. 2012;109:14966-71 pubmed publisher
Liu C, Ha M, Cui Y, Wang C, Yan M, Fu W, et al. JNK pathway decreases thyroid hormones via TRH receptor: a novel mechanism for disturbance of thyroid hormone homeostasis by PCB153. Toxicology. 2012;302:68-76 pubmed publisher
Carbone D, Zuloaga D, Lacagnina A, McGivern R, Handa R. Exposure to dexamethasone during late gestation causes female-specific decreases in core body temperature and prepro-thyrotropin-releasing hormone expression in the paraventricular nucleus of the hypothalamus in rats. Physiol Behav. 2012;108:6-12 pubmed publisher
Thal D, Homan K, Chen J, Wu E, Hinkle P, Huang Z, et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012;7:1830-9 pubmed publisher
Costa e Sousa R, Astapova I, Ye F, Wondisford F, Hollenberg A. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012;153:5049-57 pubmed
Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, et al. NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin ? gene: analysis of TRH knockout mice. PLoS ONE. 2012;7:e40437 pubmed publisher
Mijiddorj T, Kanasaki H, Purwana I, Unurjargal S, Oride A, Miyazaki K. Effects of estradiol and progesterone on prolactin transcriptional activity in somatolactotrophic cells. Endocr J. 2012;59:867-79 pubmed
Khomane K, Nandekar P, Wahlang B, Bagul P, Shaikh N, Pawar Y, et al. Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647. Mol Pharm. 2012;9:2458-68 pubmed publisher
Alvarez Salas E, Aceves C, Anguiano B, Uribe R, García Luna C, Sanchez E, et al. Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II. Endocrinology. 2012;153:4067-76 pubmed publisher
Drastichova Z, Novotny J. Identification and subcellular localization of molecular complexes of Gq/11? protein in HEK293 cells. Acta Biochim Biophys Sin (Shanghai). 2012;44:641-9 pubmed publisher
Mussa B, Verberne A. The dorsal motor nucleus of the vagus and regulation of pancreatic secretory function. Exp Physiol. 2013;98:25-37 pubmed publisher
Khomane K, Meena C, Jain R, Bansal A. Novel thyrotropin-releasing hormone analogs: a patent review. Expert Opin Ther Pat. 2011;21:1673-91 pubmed publisher
Spangle J, M nger K. The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. J Virol. 2010;84:9398-407 pubmed publisher
Nillni E. Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. Front Neuroendocrinol. 2010;31:134-56 pubmed publisher
Prokai Tatrai K, Prokai L. Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents. Molecules. 2009;14:633-54 pubmed publisher
Chiamolera M, Wondisford F. Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology. 2009;150:1091-6 pubmed publisher
Kamath J, Yarbrough G, Prange A, Winokur A. The thyrotropin-releasing hormone (TRH)-immune system homeostatic hypothesis. Pharmacol Ther. 2009;121:20-8 pubmed publisher
Monga V, Meena C, Kaur N, Jain R. Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs. Curr Med Chem. 2008;15:2718-33 pubmed
Shibusawa N, Hashimoto K, Yamada M. Thyrotropin-releasing hormone (TRH) in the cerebellum. Cerebellum. 2008;7:84-95 pubmed publisher
Carroll A, Urban S, Lamb J, Moni R, Guymer G, Forster P, et al. Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata. J Nat Prod. 2008;71:881-3 pubmed publisher
Carroll A, Lamb J, Moni R, Hooper J, Quinn R. Spongian diterpenes with thyrotropin releasing hormone receptor 2 binding affinity from Spongia sp. J Nat Prod. 2008;71:884-6 pubmed publisher
Hollenberg A. The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor. Thyroid. 2008;18:131-9 pubmed publisher
Fekete C, Lechan R. Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol. 2007;28:97-114 pubmed
Wessling S, Ross B, Koda Y, Blanchfield J, Toth I. Caco-2 cell permeability and stability of two d-glucopyranuronamide conjugates of thyrotropin-releasing hormone. Bioorg Med Chem. 2007;15:4946-50 pubmed
Engel S, Gershengorn M. Thyrotropin-releasing hormone and its receptors--a hypothesis for binding and receptor activation. Pharmacol Ther. 2007;113:410-9 pubmed
Kaur N, Monga V, Lu X, Gershengorn M, Jain R. Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg Med Chem. 2007;15:433-43 pubmed
Fekete C, Lechan R. Neuroendocrine implications for the association between cocaine- and amphetamine regulated transcript (CART) and hypophysiotropic thyrotropin-releasing hormone (TRH). Peptides. 2006;27:2012-8 pubmed
Colson A, Gershengorn M. Thyrotropin-releasing hormone analogs. Mini Rev Med Chem. 2006;6:221-6 pubmed
Hashimoto K, Yamada M, Mori M. [Expression and function of the thyrotropin-releasing hormone (TRH)]. Nihon Rinsho. 2005;63 Suppl 10:66-71 pubmed
Kaur N, Lu X, Gershengorn M, Jain R. Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2. J Med Chem. 2005;48:6162-5 pubmed
Yamada M, Umezawa R. [Thyrotropin-releasing hormone (TRH)]. Nihon Rinsho. 2005;63 Suppl 8:220-3 pubmed
Garcia S, Pirola C. Thyrotropin-releasing hormone in cardiovascular pathophysiology. Regul Pept. 2005;128:239-46 pubmed
Lechan R, Fekete C. Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome. J Endocrinol Invest. 2004;27:105-19 pubmed
Crowther C, Alfirevic Z, Haslam R. Thyrotropin-releasing hormone added to corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database Syst Rev. 2004;:CD000019 pubmed
Miller S, Warnick J. Protirelin (thyrotropin-releasing hormone) in amyotrophic lateral sclerosis. The role of androgens. Arch Neurol. 1989;46:330-5 pubmed
Angelucci L, Lorentz G, Maccari S, Patacchioli F, Scaccianoce S, Taglialatela G. [Pharmacologic profile of protirelin tartrate]. Ann Ital Med Int. 1990;5:232-44 pubmed
product information
Catalog Number :
P1319
Product Name :
Thyrotropin releasing hormone
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA